Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 

Saved Queries

Sign in to use this feature.

Search Filter Reset All

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
Add Subjects Reset
Select Subjects

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
Add Journals Reset
Select Journals

Article Types

remove_circle_outline
remove_circle_outline
Add Article Types Reset
Select Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
Add Countries / Regions Reset
Select Countries / Regions
Update Search
share announcement

Search Results (3)

Search Parameters:
Authors = Isaac Ramirez Cardenas ORCID = 0009-0009-7020-9049

Order results
Result details
Results per page
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
29 pages, 3282 KiB  
Review
A Review of Aerospike Nozzles: Current Trends in Aerospace Applications
by Isaac Ramirez Cardenas, Santiago Laín and Omar Dario Lopez
Aerospace 2025, 12(6), 519; https://doi.org/10.3390/aerospace12060519 - 9 Jun 2025
Viewed by 21483
Abstract
The aerospike nozzle has emerged as a revolutionary technology in rocket propulsion, overcoming the limitations of conventional nozzles by dynamically adjusting the expansion of exhaust gases according to ambient pressure. This results in greater efficiency and fuel savings. Thanks to advancements in materials, [...] Read more.
The aerospike nozzle has emerged as a revolutionary technology in rocket propulsion, overcoming the limitations of conventional nozzles by dynamically adjusting the expansion of exhaust gases according to ambient pressure. This results in greater efficiency and fuel savings. Thanks to advancements in materials, computational simulations, and additive manufacturing, aerospike nozzle design has surpassed historical barriers, not only enhancing the performance of multi-stage engines but also enabling the development of new space vehicles such as single-stage-to-orbit (SSTO) systems. These promise a simpler, reusable, and more cost-effective launch architecture. In summary, aerospike technology inspires a new era in space exploration, transforming propulsion efficiency and paving the way for more accessible and sustainable future space transportation systems. Full article
(This article belongs to the Section Astronautics & Space Science)
►▼ Show Figures

Figure 1

15 pages, 7940 KiB  
Article
Customizable Collagen Vitrigel Membranes and Preliminary Results in Corneal Engineering
by María Dolores Montalvo-Parra, Wendy Ortega-Lara, Denise Loya-García, Andrés Bustamante-Arias, Guillermo-Isaac Guerrero-Ramírez, Cesar E. Calzada-Rodríguez, Guiomar Farid Torres-Guerrero, Betsabé Hernández-Sedas, Italia Tatnaí Cárdenas-Rodríguez, Sergio E. Guevara-Quintanilla, Marcelo Salán-Gomez, Miguel Ángel Hernández-Delgado, Salvador Garza-González, Mayra G. Gamboa-Quintanilla, Luis Guillermo Villagómez-Valdez, Judith Zavala and Jorge E. Valdez-García
Polymers 2022, 14(17), 3556; https://doi.org/10.3390/polym14173556 - 29 Aug 2022
Cited by 5 | Viewed by 3459
Abstract
Corneal opacities are a leading cause of visual impairment that affect 4.2 million people annually. The current treatment is corneal transplantation, which is limited by tissue donor shortages. Corneal engineering aims to develop membranes that function as scaffolds in corneal cell transplantation. Here, [...] Read more.
Corneal opacities are a leading cause of visual impairment that affect 4.2 million people annually. The current treatment is corneal transplantation, which is limited by tissue donor shortages. Corneal engineering aims to develop membranes that function as scaffolds in corneal cell transplantation. Here, we describe a method for producing transplantable corneal constructs based on a collagen vitrigel (CVM) membrane and corneal endothelial cells (CECs). The CVMs were produced using increasing volumes of collagen type I: 1X (2.8 μL/mm2), 2X, and 3X. The vitrification process was performed at 40% relative humidity (RH) and 40 °C using a matryoshka-like system consisting of a shaking-oven harboring a desiccator with a saturated K2CO3 solution. The CVMs were characterized via SEM microscopy, cell adherence, FTIR, and manipulation in an ex vivo model. A pilot transplantation of the CECs/CVM construct in rabbits was also carried out. The thickness of the CVMs was 3.65–7.2 µm. The transparency was superior to a human cornea (92.6% = 1X; 94% = 2X; 89.21% = 3X). SEM microscopy showed a homogenous surface and laminar organization. The cell concentration seeded over the CVM increased threefold with no significant difference between 1X, 2X, and 3X (p = 0.323). The 2X-CVM was suitable for surgical manipulation in the ex vivo model. Constructs using the CECs/2X-CVM promoted corneal transparency restoration. Full article
(This article belongs to the Special Issue Multi-Functional Collagen-Based Biomaterials for Biomedical Applications)
►▼ Show Figures

Graphical abstract

17 pages, 5296 KiB  
Article
TCGA Pan-Cancer Genomic Analysis of Alternative Lengthening of Telomeres (ALT) Related Genes
by Isaac Armendáriz-Castillo, Andrés López-Cortés, Jennyfer García-Cárdenas, Patricia Guevara-Ramírez, Paola E. Leone, Andy Pérez-Villa, Verónica Yumiceba, Ana K. Zambrano, Santiago Guerrero and César Paz-y-Miño
Genes 2020, 11(7), 834; https://doi.org/10.3390/genes11070834 - 21 Jul 2020
Cited by 12 | Viewed by 5340
Abstract
Telomere maintenance mechanisms (TMM) are used by cancer cells to avoid apoptosis, 85–90% reactivate telomerase, while 10–15% use the alternative lengthening of telomeres (ALT). Due to anti-telomerase-based treatments, some tumors switch from a telomerase-dependent mechanism to ALT; in fact, the co-existence between both [...] Read more.
Telomere maintenance mechanisms (TMM) are used by cancer cells to avoid apoptosis, 85–90% reactivate telomerase, while 10–15% use the alternative lengthening of telomeres (ALT). Due to anti-telomerase-based treatments, some tumors switch from a telomerase-dependent mechanism to ALT; in fact, the co-existence between both mechanisms has been observed in some cancers. Although different elements in the ALT pathway are uncovered, some molecular mechanisms are still poorly understood. Therefore, with the aim to identify potential molecular markers for the study of ALT, we combined in silico approaches in a 411 telomere maintenance gene set. As a consequence, we conducted a genomic analysis of these genes in 31 Pan-Cancer Atlas studies from The Cancer Genome Atlas and found 325,936 genomic alterations; from which, we identified 20 genes highly mutated in the cancer studies. Finally, we made a protein-protein interaction network and enrichment analysis to observe the main pathways of these genes and discuss their role in ALT-related processes, like homologous recombination and homology directed repair. Overall, due to the lack of understanding of the molecular mechanisms of ALT cancers, we proposed a group of genes, which after ex vivo validations, could represent new potential therapeutic markers in the study of ALT. Full article
(This article belongs to the Section Human Genomics and Genetic Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying article 1-50 on page 1 of 1.
Back to TopTop