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Authors = Corina Cuceu-Petrenci

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18 pages, 2786 KiB  
Review
Safety Testing of Cosmetic Products: Overview of Established Methods and New Approach Methodologies (NAMs)
by Manon Barthe, Clarisse Bavoux, Francis Finot, Isabelle Mouche, Corina Cuceu-Petrenci, Andy Forreryd, Anna Chérouvrier Hansson, Henrik Johansson, Gregory F. Lemkine, Jean-Paul Thénot and Hanan Osman-Ponchet
Cosmetics 2021, 8(2), 50; https://doi.org/10.3390/cosmetics8020050 - 11 Jun 2021
Cited by 40 | Viewed by 38349
Abstract
Cosmetic products need to have a proven efficacy combined with a comprehensive toxicological assessment. Before the current Cosmetic regulation N°1223/2009, the 7th Amendment to the European Cosmetics Directive has banned animal testing for cosmetic products and for cosmetic ingredients in 2004 and 2009, [...] Read more.
Cosmetic products need to have a proven efficacy combined with a comprehensive toxicological assessment. Before the current Cosmetic regulation N°1223/2009, the 7th Amendment to the European Cosmetics Directive has banned animal testing for cosmetic products and for cosmetic ingredients in 2004 and 2009, respectively. An increasing number of alternatives to animal testing has been developed and validated for safety and efficacy testing of cosmetic products and cosmetic ingredients. For example, 2D cell culture models derived from human skin can be used to evaluate anti-inflammatory properties, or to predict skin sensitization potential; 3D human skin equivalent models are used to evaluate skin irritation potential; and excised human skin is used as the gold standard for the evaluation of dermal absorption. The aim of this manuscript is to give an overview of the main in vitro and ex vivo alternative models used in the safety testing of cosmetic products with a focus on regulatory requirements, genotoxicity potential, skin sensitization potential, skin and eye irritation, endocrine properties, and dermal absorption. Advantages and limitations of each model in safety testing of cosmetic products are discussed and novel technologies capable of addressing these limitations are presented. Full article
(This article belongs to the Special Issue Current and Evolving Practices in the Quality Control of Cosmetics)
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