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Search Results (6)

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Authors = Anudari Ulziibayar ORCID = 0000-0002-5064-0634

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19 pages, 3574 KiB  
Review
Recent Tissue Engineering Approaches to Mimicking the Extracellular Matrix Structure for Skin Regeneration
by Rikako Hama, James W. Reinhardt, Anudari Ulziibayar, Tatsuya Watanabe, John Kelly and Toshiharu Shinoka
Biomimetics 2023, 8(1), 130; https://doi.org/10.3390/biomimetics8010130 - 22 Mar 2023
Cited by 48 | Viewed by 8633
Abstract
Inducing tissue regeneration in many skin defects, such as large traumatic wounds, burns, other physicochemical wounds, bedsores, and chronic diabetic ulcers, has become an important clinical issue in recent years. Cultured cell sheets and scaffolds containing growth factors are already in use but [...] Read more.
Inducing tissue regeneration in many skin defects, such as large traumatic wounds, burns, other physicochemical wounds, bedsores, and chronic diabetic ulcers, has become an important clinical issue in recent years. Cultured cell sheets and scaffolds containing growth factors are already in use but have yet to restore normal skin tissue structure and function. Many tissue engineering materials that focus on the regeneration process of living tissues have been developed for the more versatile and rapid initiation of treatment. Since the discovery that cells recognize the chemical–physical properties of their surrounding environment, there has been a great deal of work on mimicking the composition of the extracellular matrix (ECM) and its three-dimensional network structure. Approaches have used ECM constituent proteins as well as morphological processing methods, such as fiber sheets, sponges, and meshes. This review summarizes material design strategies in tissue engineering fields, ranging from the morphology of existing dressings and ECM structures to cellular-level microstructure mimicry, and explores directions for future approaches to precision skin tissue regeneration. Full article
(This article belongs to the Special Issue Biomimetic Platform for Tissue Regeneration 2.0)
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21 pages, 1676 KiB  
Review
The Application of Porous Scaffolds for Cardiovascular Tissues
by Tatsuya Watanabe, Salha Sassi, Anudari Ulziibayar, Rikako Hama, Takahiro Kitsuka and Toshiharu Shinoka
Bioengineering 2023, 10(2), 236; https://doi.org/10.3390/bioengineering10020236 - 10 Feb 2023
Cited by 11 | Viewed by 3464
Abstract
As the number of arteriosclerotic diseases continues to increase, much improvement is still needed with treatments for cardiovascular diseases. This is mainly due to the limitations of currently existing treatment options, including the limited number of donor organs available or the long-term durability [...] Read more.
As the number of arteriosclerotic diseases continues to increase, much improvement is still needed with treatments for cardiovascular diseases. This is mainly due to the limitations of currently existing treatment options, including the limited number of donor organs available or the long-term durability of the artificial organs. Therefore, tissue engineering has attracted significant attention as a tissue regeneration therapy in this area. Porous scaffolds are one of the effective methods for tissue engineering. However, it could be better, and its effectiveness varies depending on the tissue application. This paper will address the challenges presented by various materials and their combinations. We will also describe some of the latest methods for tissue engineering. Full article
(This article belongs to the Special Issue Advances in Cardiovascular Tissue-Engineering)
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16 pages, 1862 KiB  
Review
Recent Developments in Biopolymer-Based Hydrogels for Tissue Engineering Applications
by Rikako Hama, Anudari Ulziibayar, James W. Reinhardt, Tatsuya Watanabe, John Kelly and Toshiharu Shinoka
Biomolecules 2023, 13(2), 280; https://doi.org/10.3390/biom13020280 - 2 Feb 2023
Cited by 66 | Viewed by 5930
Abstract
Hydrogels are being investigated for their application in inducing the regeneration of various tissues, and suitable conditions for each tissue are becoming more apparent. Conditions such as the mechanical properties, degradation period, degradation mechanism, and cell affinity can be tailored by changing the [...] Read more.
Hydrogels are being investigated for their application in inducing the regeneration of various tissues, and suitable conditions for each tissue are becoming more apparent. Conditions such as the mechanical properties, degradation period, degradation mechanism, and cell affinity can be tailored by changing the molecular structure, especially in the case of polymers. Furthermore, many high-functional hydrogels with drug delivery systems (DDSs), in which drugs or bioactive substances are contained in controlled hydrogels, have been reported. This review focuses on the molecular design and function of biopolymer-based hydrogels and introduces recent developments in functional hydrogels for clinical applications. Full article
(This article belongs to the Special Issue Novel Materials for Biomedical Applications)
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14 pages, 1164 KiB  
Review
Advances in Cardiac Tissue Engineering
by Takahiro Kitsuka, Fuga Takahashi, James Reinhardt, Tatsuya Watanabe, Anudari Ulziibayar, Asigul Yimit, John Kelly and Toshiharu Shinoka
Bioengineering 2022, 9(11), 696; https://doi.org/10.3390/bioengineering9110696 - 16 Nov 2022
Cited by 8 | Viewed by 3306
Abstract
Tissue engineering has paved the way for the development of artificial human cardiac muscle patches (hCMPs) and cardiac tissue analogs, especially for treating Myocardial infarction (MI), often by increasing its regenerative abilities. Low engraftment rates, insufficient clinical application scalability, and the creation of [...] Read more.
Tissue engineering has paved the way for the development of artificial human cardiac muscle patches (hCMPs) and cardiac tissue analogs, especially for treating Myocardial infarction (MI), often by increasing its regenerative abilities. Low engraftment rates, insufficient clinical application scalability, and the creation of a functional vascular system remain obstacles to hCMP implementation in clinical settings. This paper will address some of these challenges, present a broad variety of heart cell types and sources that can be applied to hCMP biomanufacturing, and describe some new innovative methods for engineering such treatments. It is also important to note the injection/transplantation of cells in cardiac tissue engineering. Full article
(This article belongs to the Special Issue Advances in Cardiac Tissue Engineering)
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15 pages, 888 KiB  
Review
Clinical Application for Tissue Engineering Focused on Materials
by Takahiro Kitsuka, Rikako Hama, Anudari Ulziibayar, Yuichi Matsuzaki, John Kelly and Toshiharu Shinoka
Biomedicines 2022, 10(6), 1439; https://doi.org/10.3390/biomedicines10061439 - 17 Jun 2022
Cited by 17 | Viewed by 4228
Abstract
Cardiovascular-related medical conditions remain a significant cause of death worldwide despite the advent of tissue engineering research more than half a century ago. Although autologous tissue is still the preferred treatment, donor tissue is limited, and there remains a need for tissue-engineered vascular [...] Read more.
Cardiovascular-related medical conditions remain a significant cause of death worldwide despite the advent of tissue engineering research more than half a century ago. Although autologous tissue is still the preferred treatment, donor tissue is limited, and there remains a need for tissue-engineered vascular grafts (TEVGs). The production of extensive vascular tissue (>1 cm3) in vitro meets the clinical needs of tissue grafts and biological research applications. The use of TEVGs in human patients remains limited due to issues related to thrombogenesis and stenosis. In addition to the advancement of simple manufacturing methods, the shift of attention to the combination of synthetic polymers and bio-derived materials and cell sources has enabled synergistic combinations of vascular tissue development. This review details the selection of biomaterials, cell sources and relevant clinical trials related to large diameter vascular grafts. Finally, we will discuss the remaining challenges in the tissue engineering field resulting from complex requirements by covering both basic and clinical research from the perspective of material design. Full article
(This article belongs to the Special Issue Clinical Application for Tissue Engineering)
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16 pages, 961 KiB  
Review
Heparin-Eluting Tissue-Engineered Bioabsorbable Vascular Grafts
by Yuichi Matsuzaki, Anudari Ulziibayar, Toshihiro Shoji and Toshiharu Shinoka
Appl. Sci. 2021, 11(10), 4563; https://doi.org/10.3390/app11104563 - 17 May 2021
Cited by 18 | Viewed by 3547
Abstract
The creation of small-diameter tissue-engineered vascular grafts using biodegradable materials has the potential to change the quality of cardiovascular surgery in the future. The implantation of these tissue-engineered arterial grafts has yet to reach clinical application. One of the reasons for this is [...] Read more.
The creation of small-diameter tissue-engineered vascular grafts using biodegradable materials has the potential to change the quality of cardiovascular surgery in the future. The implantation of these tissue-engineered arterial grafts has yet to reach clinical application. One of the reasons for this is thrombus occlusion of the graft in the acute phase. In this paper, we first describe the causes of accelerated thrombus formation and discuss the drugs that are thought to inhibit thrombus formation. We then review the latest research on methods to locally bind the anticoagulant heparin to biodegradable materials and methods to extend the duration of sustained heparin release. We also discuss the results of studies using large animal models and the challenges that need to be overcome for future clinical applications. Full article
(This article belongs to the Special Issue Nature or Synthetic Compounds for Treating Arterial Thrombosis and Ischemic Stroke)
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