Search Results (3)

This study investigated the chemical composition and potential antibacterial activity of the essential oils from the propolis of Melipona quadrifasciata quadrifasciata (MQP) in samples collected from the cities of Paranaguá and Guaratuba, Paraná, Brazil, during summer and winter. The chemical composition of the oils was analyzed by GC-MS, and their minimum inhibitory concentration (MIC) was determined against standard ATCC strains and some clinical isolates (Escherichia coli 06 and Staphylococcus aureus 10). The essential oils’ MICs were determined using microdilution in 96-well plates and showed no significant antibacterial activity (MIC ≥ 1024 μg/mL) when used alone. However, the essential oils enhanced the action of norfloxacin, gentamicin, and ampicillin, especially against S. aureus 10. The chemical analysis identified 68 compounds, with β-bisabolene and β-caryophyllene as the predominant constituents. Subsequently, the antibiotic-enhancing activity against the clinical isolates was evaluated. The composition of the MQP oils varied according to seasonality and location, influenced by the microclimates of the cities. The results highlight the importance of MQP oils in enhancing antibiotic activity, particularly against Gram-positive bacteria, despite the lack of significant standalone antibacterial activity. Full article

Copaifera sp. is a native tree in the Amazon region. Copaiba oleoresin has components such as sesquiterpenes, which have anti-inflammatory and antioxidant potential. Liver cirrhosis is the end stage of liver disease with limited therapeutic options. We aimed to evaluate the effect of copaiba oleoresin supplementation on the liver of animals with thioacetamide (TAA)-induced cirrhosis. For the induction of liver cirrhosis, 100 mg/kg of TAA was administered intraperitoneally twice a week for 8 weeks. A total of 200 mg/kg/day of copaiba oleoresin was administered via gavage for the same period. Copaiba oleoresin supplementation improved cirrhosis-associated cachexia by increasing weight gain and body fat. In addition, copaiba oleoresin attenuated systemic inflammation, as shown by the decrease in the circulating C-reactive protein. In the liver, the copaiba oleoresin decreased carbonyl proteins and increased IL-10 compared with TAA-treated rats. TAA groups demonstrated increased SOD, catalase, GST, and GSH activity in the liver. In conclusion, the supplementation of copaiba oleoresin demonstrated a beneficial systemic effect in alleviating cirrhotic cachexia and antioxidant and anti-inflammatory action in the liver. However, it failed to improve the serological and histological markers of liver damage, which could be associated with the advanced stage of the disease. Full article

Undergraduate Research (UR) is an institutional program that introduces undergraduate students to scientific research. The program selects research projects proposed by advisors and students for execution. Despite the importance of knowing the stages of research activities in undergraduate research, only a few studies have evaluated data on this subject. Therefore, this study aims to outline an overview of UR in a Brazilian educational institution, considering the profiles of students and advisors, students’ scientific productions, and perceptions about the experience of both. The study was a mixed-approach case study conducted through a questionnaire and interviews. The sample consisted of 213 undergraduate students and 167 UR supervisors. The results show that the largest group of students were aged 21 and 22 (46.6%) and supervisors 33 to 38 years (38.9%). Regarding the scientific productions of students, those who participated twice or more in undergraduate research had higher indicators compared to those who were participating for the first time. Students’ perceptions of their evolution and perceptions of the advisors were mostly positive, with a greater number of responses classified as very good to good. Thus, the satisfaction of researchers in being part of this experience was perceived and the need to improve the scientific production indicators of students, mediated by the advisors stimulating the writing of articles, abstracts, and books, as well as participation in events and patent development, was shown. We conclude that undergraduate research activities promote the integral development of students’ academic, scientific, personal, and professional terms, which ultimately reflect critical and emancipatory actions in society. Full article