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Authors = Abha Jain

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14 pages, 1911 KiB  
Systematic Review
Seed Storage Protein, Functional Diversity and Association with Allergy
by Abha Jain
Allergies 2023, 3(1), 25-38; https://doi.org/10.3390/allergies3010003 - 18 Jan 2023
Cited by 16 | Viewed by 8708
Abstract
Plants are essential for humans as they serve as a source of food, fuel, medicine, oils, and more. The major elements that are utilized for our needs exist in storage organs, such as seeds. These seeds are rich in proteins, show a broad [...] Read more.
Plants are essential for humans as they serve as a source of food, fuel, medicine, oils, and more. The major elements that are utilized for our needs exist in storage organs, such as seeds. These seeds are rich in proteins, show a broad spectrum of physiological roles, and are classified based on their sequence, structure, and conserved motifs. With the improvements to our knowledge of the basic sequence and our structural understanding, we have acquired better insights into seed proteins and their role. However, we still lack a systematic analysis towards understanding the functional diversity associated within each family and their associations with allergy. This review puts together the information about seed proteins, their classification, and diverse functional roles along with their associations with allergy. Full article
(This article belongs to the Special Issue Fruit Allergies, New Emerging Allergens)
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34 pages, 5167 KiB  
Review
Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials
by Atif Khurshid Wani, Nahid Akhtar, Tahir ul Gani Mir, Rattandeep Singh, Prakash Kumar Jha, Shyam Kumar Mallik, Shruti Sinha, Surya Kant Tripathi, Abha Jain, Aprajita Jha, Hari Prasad Devkota and Ajit Prakash
Biomolecules 2023, 13(2), 194; https://doi.org/10.3390/biom13020194 - 18 Jan 2023
Cited by 83 | Viewed by 14981
Abstract
Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly regulated through membrane channels and apoptogenic proteins. Apoptosis maintains cellular balance within the human body through cell cycle [...] Read more.
Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly regulated through membrane channels and apoptogenic proteins. Apoptosis maintains cellular balance within the human body through cell cycle progression. Loss of apoptosis control prolongs cancer cell survival and allows the accumulation of mutations that can promote angiogenesis, promote cell proliferation, disrupt differentiation, and increase invasiveness during tumor progression. The apoptotic pathway has been extensively studied as a potential drug target in cancer treatment. However, the off-target activities of drugs and negative implications have been a matter of concern over the years. Phytochemicals (PCs) have been studied for their efficacy in various cancer cell lines individually and synergistically. The development of nanoparticles (NPs) through green synthesis has added a new dimension to the advancement of plant-based nanomaterials for effective cancer treatment. This review provides a detailed insight into the fundamental molecular pathways of programmed cell death and highlights the role of PCs along with the existing drugs and plant-based NPs in treating cancer by targeting its programmed cell death (PCD) network. Full article
(This article belongs to the Special Issue New Advances in Natural Products in Drug Discovery)
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