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Article

Health-Related Quality of Life and Satisfaction in Atrial Fibrillation Patients on Anticoagulant Therapy: Differences between Vitamin K Antagonists and Direct Oral Anticoagulants; Results from the Multicentre REGUEIFA Registry

by
Pilar Cabanas-Grandío
1,
Laila González-Melchor
2,
María Vázquez Caamaño
3,
Emiliano Fernández-Obanza Windcheid
4,
Eva González Babarro
5,
Olga Durán Bobín
6,
Miriam Piñeiro Portela
7,
Oscar Prada Delgado
7,
Juliana Elices Teja
6,
Mario Gutiérrez Feijoo
8,
Evaristo Freire
8,
Oscar Díaz Castro
1,
Javier Muñiz García
9,
Javier García-Seara
2 and
Carlos González-Juanatey
6,*
1
Cardiology Department, Hospital Álvaro Cunqueiro, 36312 Vigo, Spain
2
Cardiology Department, Hospital Clínico de Santiago de Compostela, 15706 A Coruña, Spain
3
Cardiology Department, Hospital Povisa, 36211 Vigo, Spain
4
Cardiology Department, Hospital Arquitecto Marcide, 15405 Ferrol, A Coruña, Spain
5
Cardiology Department, Hospital de Montecelo, 36071 Pontevedra, Spain
6
Cardiology Department, Hospital Universitario Lucus Augusti, 27002 Lugo, Spain
7
Cardiology Department, Complexo Hospitalario Universitario de A Coruña, Instituto de Investigación Biomédica de A Coruña (INIBIC), 15006 A Coruña, Spain
8
Cardiology Department, Hospital de Ourense, 32005 Ourense, Spain
9
Odds S.L., 15005 A Coruña, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2024, 13(17), 5283; https://doi.org/10.3390/jcm13175283
Submission received: 3 June 2024 / Revised: 12 July 2024 / Accepted: 6 August 2024 / Published: 6 September 2024
(This article belongs to the Section Cardiology)
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Abstract

Background: Oral anticoagulation (OAC) is pivotal in the clinical management of atrial fibrillation (AF) patients. Vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs) prevent thromboembolic events, but information about the quality of life (QoL) and patient satisfaction in relation with the anticoagulant treatment is limited. Methods: REGUEIFA is a prospective, observational, and multicentre study that included patients with AF treated by cardiologists. We included patients treated with VKAs or DOACs. The EuroQol-5D (EQ-5D) questionnaire evaluated QoL, and the Anti-Clot Treatment Scale (ACTS) questionnaire investigated patient satisfaction with OAC. Results: A total of 904 patients were included (532 on VKA and 372 on DOACs). A total of 846 patients completed the EQ-5D questionnaire, with results significantly worse in patients on VKAs than on DOACs: more mobility limitations (37.6% vs. 24.2%, p < 0.001), more restriction in usual activities (24.7% vs. 18.3%, p = 0.026), more pain/discomfort (31.8% vs. 24.2%, p = 0.015), a lower visual analogue scale (VAS) score (66.4 ± 16.21 vs. 70.8 ± 15.6), and a lower EQ-D5 index (0.79 ± 0.21 vs. 0.85 ± 0.2, p < 0.001). After adjusting for baseline characteristics, VKA treatment was not an independent factor towards worse EQ-5D results. Also, 738 patients completed the ACTS questionnaire, and burden and profit scores were lower in patients on VKAs than for DOACs (52.1 ± 8.4 vs. 55.5 ± 6.8, p < 0.001 and 11.1 ± 2.4 vs. 11.8 ± 2.6, p < 0.001, respectively). The negative impact score was higher for VKAs than for DOACs (1.8 ± 1.02 vs. 1.6 ± 0.99, p < 0.001), with a general positive impact score lower for VKAs than for DOACs (3.6 ± 0.96 vs. 3.8 ± 1.02, p < 0.001). Conclusions: Patients on VKA have more comorbidity and worse EQ-5D and VAS scores than those on DOACs. VKA has a greater burden and higher negative impact on the patient’s life than DOACs.
Keywords: quality of life; patient satisfaction; atrial fibrillation; oral anticoagulation quality of life; patient satisfaction; atrial fibrillation; oral anticoagulation

Share and Cite

MDPI and ACS Style

Cabanas-Grandío, P.; González-Melchor, L.; Caamaño, M.V.; Windcheid, E.F.-O.; Babarro, E.G.; Bobín, O.D.; Portela, M.P.; Delgado, O.P.; Teja, J.E.; Feijoo, M.G.; et al. Health-Related Quality of Life and Satisfaction in Atrial Fibrillation Patients on Anticoagulant Therapy: Differences between Vitamin K Antagonists and Direct Oral Anticoagulants; Results from the Multicentre REGUEIFA Registry. J. Clin. Med. 2024, 13, 5283. https://doi.org/10.3390/jcm13175283

AMA Style

Cabanas-Grandío P, González-Melchor L, Caamaño MV, Windcheid EF-O, Babarro EG, Bobín OD, Portela MP, Delgado OP, Teja JE, Feijoo MG, et al. Health-Related Quality of Life and Satisfaction in Atrial Fibrillation Patients on Anticoagulant Therapy: Differences between Vitamin K Antagonists and Direct Oral Anticoagulants; Results from the Multicentre REGUEIFA Registry. Journal of Clinical Medicine. 2024; 13(17):5283. https://doi.org/10.3390/jcm13175283

Chicago/Turabian Style

Cabanas-Grandío, Pilar, Laila González-Melchor, María Vázquez Caamaño, Emiliano Fernández-Obanza Windcheid, Eva González Babarro, Olga Durán Bobín, Miriam Piñeiro Portela, Oscar Prada Delgado, Juliana Elices Teja, Mario Gutiérrez Feijoo, and et al. 2024. "Health-Related Quality of Life and Satisfaction in Atrial Fibrillation Patients on Anticoagulant Therapy: Differences between Vitamin K Antagonists and Direct Oral Anticoagulants; Results from the Multicentre REGUEIFA Registry" Journal of Clinical Medicine 13, no. 17: 5283. https://doi.org/10.3390/jcm13175283

APA Style

Cabanas-Grandío, P., González-Melchor, L., Caamaño, M. V., Windcheid, E. F.-O., Babarro, E. G., Bobín, O. D., Portela, M. P., Delgado, O. P., Teja, J. E., Feijoo, M. G., Freire, E., Castro, O. D., García, J. M., García-Seara, J., & González-Juanatey, C. (2024). Health-Related Quality of Life and Satisfaction in Atrial Fibrillation Patients on Anticoagulant Therapy: Differences between Vitamin K Antagonists and Direct Oral Anticoagulants; Results from the Multicentre REGUEIFA Registry. Journal of Clinical Medicine, 13(17), 5283. https://doi.org/10.3390/jcm13175283

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