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Venereology
Special Issues
Antimicrobial Resistant Sexually Transmitted Infections: Epidemiology, Detection, and Management
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Antimicrobial Resistant Sexually Transmitted Infections: Epidemiology, Detection, and Management

A special issue of Venereology (ISSN 2674-0710).

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 5116

Special Issue Editors

Dr. Karan Varshney

E-Mail Website
Guest Editor
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Interests: antimicrobial resistance; infectious disease; tuberculosis; HIV; sexually transmitted infections; co-infection
Prof. Dr. Michael Ross

E-Mail Website
Guest Editor
Program in Human Sexuality, Department of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, MN, USA
Interests: HIV and STI epidemiology; education and prevention in MSM and sex workers

Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) has become one of the most critical public health problems of our time, and we have begun to enter the post-antibiotic era. AMR in sexually transmitted infections is an increasing concern, and there is a clear need to understand the scope of this problem, and to determine the most appropriate methods of management and techniques of detection.

In this Special Issue, we are therefore seeking to receive submissions regarding AMR in sexually transmitted infections, as well as innovative ways to address this problem.

Dr. Karan Varshney
Prof. Dr. Michael Ross
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Venereology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance
  • antibiotics
  • pan-resistance
  • sexually transmitted infections
  • infection control
  • detection

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Published Papers (3 papers)

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Editorial

Jump to: Research, Review

2 pages, 198 KiB  
Editorial
The Emerging Threat of Antimicrobial-Resistant Sexually Transmitted Infections: Epidemiology, Management and Detection
by Karan Varshney
Venereology 2023, 2(2), 76-77; https://doi.org/10.3390/venereology2020007 - 19 May 2023
Cited by 1 | Viewed by 1690
Abstract
Antimicrobial resistance (AMR) has become one of the most pressing public health crises, with sexually transmitted infections (STIs) of all types rapidly becoming resistant to treatments [...] Full article
(This article belongs to the Special Issue Antimicrobial Resistant Sexually Transmitted Infections: Epidemiology, Detection, and Management)

Research

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8 pages, 1298 KiB  
Article
Modulatory Effect of Human Immunodeficiency Virus on Circulating p53, miR-21, and miR-125b: Any Diagnostic Implication?
by Jude Ogechukwu Okoye, Anthony Ajuluchukwu Ngokere, Chinedum Charles Onyenekwe, Olaposi Idowu Omotuyi, Samuel Ifedioranma Ogenyi, Chioma Maureen Obi and Samuel Ayobami Fasogbon
Venereology 2023, 2(3), 78-85; https://doi.org/10.3390/venereology2030008 - 25 Jun 2023
Viewed by 1900
Abstract
Identifying immunocompromised women who are at risk of developing cervical cancer remains a challenge for clinicians. In an effort to identify the role of HIV in cervical carcinogenesis, this study evaluated the levels of normally downregulated oncomirs (miR-21, miR-146a, miR-155, miR-182, and miR-200c) [...] Read more.
Identifying immunocompromised women who are at risk of developing cervical cancer remains a challenge for clinicians. In an effort to identify the role of HIV in cervical carcinogenesis, this study evaluated the levels of normally downregulated oncomirs (miR-21, miR-146a, miR-155, miR-182, and miR-200c) and normally upregulated tumor suppressors (miR-let-7b, miR-125b, miR-143, miR-145, and p53 expression) associated with cervical cancer in the serum of women living with HIV (HIV+) and without HIV (HIV. Method: This case-control study included 173 women; confirmed HIV+ (n = 103) and HIV− (n = 70). Serum levels of miRNAs and p53 were determined using reverse transcriptase PCR. t-test and Pearson’s correlation analyses were carried out on the generated data. Result: A higher level of miR-21 was observed among HIV+ women compared with their HIV− counterpart (p = 0.028), whereas lower levels of miR-125, and p53 gene were observed among HIV+ women compared with HIV− women at p = 0.050 and 0.049, respectively. Significant direct relationships were observed between miR-21 and other oncomirs (p < 0.05) among HIV+ women. Conclusion: This study revealed that HIV contributes to cervical carcinogenesis by modulating circulating levels of miR-21, p53, and miR-125b. It suggests that these biomarkers could be used to identify at high risk for developing cervical cancer. Full article
(This article belongs to the Special Issue Antimicrobial Resistant Sexually Transmitted Infections: Epidemiology, Detection, and Management)
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Review

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16 pages, 2824 KiB  
Review
The Crosstalk Between HIV-TB Co-Infection and Associated Resistance in the Indian Population
by Sushama Jadhav, Aishwarya Nair, Pratik Mahajan and Vijay Nema
Venereology 2024, 3(4), 183-198; https://doi.org/10.3390/venereology3040015 - 6 Nov 2024
Viewed by 808
Abstract
Extensive research on tuberculosis (TB) and HIV co-infection reveals the diverse prevalence and co-epidemic patterns across populations, necessitating tailored public health strategies. Co-infection is bidirectional; individuals with HIV are more susceptible to TB, and vice versa. Antiretroviral therapy (ART) and antituberculosis treatment (ATT) [...] Read more.
Extensive research on tuberculosis (TB) and HIV co-infection reveals the diverse prevalence and co-epidemic patterns across populations, necessitating tailored public health strategies. Co-infection is bidirectional; individuals with HIV are more susceptible to TB, and vice versa. Antiretroviral therapy (ART) and antituberculosis treatment (ATT) are critical for managing these conditions, but pose risks due to drug–pathogen and drug–drug interactions, potentially leading to immune reconstitution inflammatory syndrome (IRIS) in patients with HIV/AIDS. IRIS, often triggered by highly active antiretroviral therapy (HAART), can exacerbate HIV progression, increase drug resistance, and deteriorate patients’ quality of life. Approximately one-third of the global population with HIV is also infected with TB, with extensive drug-resistant (XDR) and multidrug-resistant (MDR) strains posing significant challenges. Latent TB infection (LTBI) further complicates the scenario, as it can progress to active TB, particularly in individuals with both conditions. The global and Indian mortality rates for TB-HIV co-infection remain high, emphasizing the need for new strategies. Additionally, unreported cases and inadequate post-treatment monitoring contribute to the high mortality rate, particularly among patients with LTBI. The complexity of managing HIV-TB co-infection, especially with LTBI, underscores the urgency of addressing these challenges to improve the outcomes for the affected populations. Full article
(This article belongs to the Special Issue Antimicrobial Resistant Sexually Transmitted Infections: Epidemiology, Detection, and Management)
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