Special Issue "Neuroprotective Role of Glial Cells in Cerebral Ischemia"

A special issue of Neuroglia (ISSN 2571-6980).

Deadline for manuscript submissions: closed (20 November 2021) | Viewed by 319

Special Issue Editor

Institut National de la Santé et de la Recherche (INSERM), Universite Paris 7- Denis Diderot, Paris, France
Interests: cerebral ischemia; neonates; cell death; inflammation; microglia; hemodynamic responses; ultrasound imaging; nitric oxide; prostaglandins

Special Issue Information

Dear Colleagues,

Stroke is a disorder affecting all age groups, particularly those at opposite ends of the age spectrum, with an incidence of 1/2800 to 1/5000 live infant births, and more than 6 million cases every year of adult stroke, respectively. To date, there is still no effective treatment that increases the survival rate or improves the quality of life, both during the neonatal period (the first 28 days of life) and/or in adulthood. During the last decade, the male sex appeared to be a determinant factor, not only in a worse outcome (during the first 40–50 years of life), but also in response to cellular and molecular pathways activated in different cerebral areas involved in behavioral functions.

Stroke triggers dysfunction in several pathways, with multiple final outcomes, which include multiple paths to death or recovery. The activation of resident microglial cells, alongside the infiltration of peripheral macrophages, represents a central inflammatory response to ischemic stroke leading to secondary injury cascade associated with neuronal death.

Microglia/macrophages are the main players in propagating inflammation to tissues neighboring the core site of injury. They perform this task through the production of inflammatory mediators including cytokines and chemokines.

For this Special Issue, we request the submission of manuscripts concerning the molecular pathways in microglia/macrophages and immune cells (infiltration of peripheral myeloid cells including polymorphonuclear cells, lymphocytes, and monocytes), and astrocyte responses after stroke in pre-clinical studies.

Potential topics include:

  • Specific glial genes and region differences between male and female brains;
  • Specific glial responses according to the developmental stage of ischemic animals;
  • Specific glial responses according to rodent species used in stroke models.

These data may highlight the development of additional sex-specific therapeutic strategies in stroke units.

Prof. Dr. Christiane Charriaut-Marlangue
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Neuroglia is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • astrocytes
  • microglia
  • cell death
  • M2 phenotype
  • M1 phenotype
  • M-Trans phenotype
  • neonatal ischemia
  • adult ischemia
  • neurovascular unit
  • rat
  • mouse
  • cortex
  • blood–brain barrier
  • female
  • male

Published Papers

There is no accepted submissions to this special issue at this moment.
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