Immunohistochemistry in Dermatopathology

Immunopathology is an ancillary technique that has evolved in the past 40 years and continues to rapidly evolve. This procedure allows diagnosticians to analyze cellular characteristics not seen on routinely stained sections. The scientific methods behind the process have remained largely unchanged, but techniques designed to enhance sensitivity and specificity are being developed and perfected continuously. In addition, immunologic markers available to pathologists are constantly discovered and becoming progressively more sophisticated. In modern dermatopathology, this diagnostic tool not only aids in solving the dilemma of differential diagnoses but also assists in the classification of various cutaneous entities. Testing for immunohistochemical expression of particular markers to determine treatment options and efficacy is already implemented in other pathology subspecialties and will potentially be used in dermatopathology as well. To successfully orchestrate the art of immunohistochemistry, one should be broadly familial with its advantages and pitfalls and be, in general, “on top of the game” when new markers become commercially available. In this Special Issue, we aim to update the reader on the most advantageous as well as new immunohistochemical markers available for dermatopathologists.

Prof. Dr. Bruce R. Smoller
Dr. Tatsiana Pukhalskaya
Guest Editors

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• immunohistochemistry
• dermatopathology
• immunofluorescence
• tissue staining