Biomaterials and Bone

A special issue of Biophysica (ISSN 2673-4125).

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 1187

Special Issue Editor


E-Mail Website
Guest Editor
1. Chief of Orthopedic and Traumatology Dept., Sant’Anna University Hospital of Ferrara, Via Aldo Moro 8, 44124 Cona, Ferrara, Italy
2. Department of Biomedical and Speciality Surgical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy
Interests: spine surgery; hip surgery; trauma surgery; biophysical stimulation of bone and cartilage; regenerative orthopaedic medicine; use of physical forces in orthopaedics and traumatology; biomaterial interaction with bone

Special Issue Information

Dear Colleagues,

Developing of Biomaterials permitted to make huge progress in the treatment of different diseases and clinical problems, as well as to consistently improve the functions and the quality of life of a large amount of patients.

We can’t imagine how can we treat a patient affected by hip or knee osteoarthritis at an advanced stage without using joint replacement systems made of biomaterials. The same is true for dental implants and for ENT/maxillofacial surgery.

The interactions between bone and biomaterials are very interesting in terms of bone reaction to different materials to create an optimal and durable osteointegration so as to avoid complications during movement and/or loading.

Today, we have a variety of biomaterials for bone implants, with or without “biological” coating, for different clinical uses, such as interbody spinal implants, hip/knee/ankle/shoulder replacement, dental implants, maxillofacial implants, and so on.

In this Special Issue, we welcome papers on experimental and clinical aspects of interaction between bone and biomaterials, such as engineering and biophysical methods for new materials, new clinical applications, and enhancing osteointegration.

Prof. Dr. Leo Massari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biophysica is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteointegration
  • biomaterials
  • bone cells and biomaterials
  • stem cell behavior and biomaterials

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

42 pages, 8616 KiB  
Review
Cancellous Skeleton, Microskeleton, Ultramicroskeleton: A Geo/Biomorphological Bone Mineral Microbiome of Hierarchical Force Translation and Ancient Golgi-Directed Lineage
by Jean E. Aaron
Biophysica 2024, 4(3), 369-410; https://doi.org/10.3390/biophysica4030026 - 22 Aug 2024
Viewed by 761
Abstract
Bone minerals may be more complex than the prevailing opinion suggests. Understanding its biomaterial properties in health and disease may address fundamental geo/biomorphological ambiguities recurrent within its calcified cancellous hierarchy of macro-, micro-, and nano-skeletal networks. (i) There is evidence that the outer [...] Read more.
Bone minerals may be more complex than the prevailing opinion suggests. Understanding its biomaterial properties in health and disease may address fundamental geo/biomorphological ambiguities recurrent within its calcified cancellous hierarchy of macro-, micro-, and nano-skeletal networks. (i) There is evidence that the outer mineral macroskeleton of interconnected trabeculae (150 µm diameter) is modulated according to axes of tensile stress by permeating arrays of periosteal Sharpey’s fibres (collagen type III/VI, 5–25 µm thick) studded with tenascin organiser protein. (ii) Its substructural mineral microskeleton is a reticulation of bridged and deformable calcium phosphate/carbonate microspheres (about 1 µm diameter). These organically enshrouded (e.g., bone sialoprotein, osteocalcin, osteopontin) objects, configured by the adhesive organiser protein fibronectin and tempered by trace elements (e.g., Si, Mg, Fe, Al), display differential histochemistry (e.g., acid phosphatase, carbonic anhydrase) and anomalous traits (tetracycline binding, gram-positive microbial staining and nucleic acid staining affinity). The calcified microspheres are intracellular fabrications of osteocyte cohorts developed within “switched on” Golgi cisternae prior to aggregation at the extracellular calcification front in chains and looped assemblies. (iii) Within each microsphere, a less dense centre is encircled by a mineral nanoskeleton of beaded filaments (5 nm in diameter) transmutable in electron density, with a trait for lateral fusion into ladder-like struts, stays and senescent fenestrated plates, constituting domains of microparticle slip and crystal fracture. The evidence suggests a bone mineral biosystem of integrated complexity within which a particulate assemblage at the animate: inanimate calcification front resembles a colonial construct of prokaryote-like, Golgi-fabricated objects calcified with phosphate and harbouring a resident biochemistry. A self-contained “Petrified Microbiome” is proposed to be orchestrated according to a biodynamic primordial paradigm. Full article
(This article belongs to the Special Issue Biomaterials and Bone)
Show Figures

Figure 1

Back to TopTop