The “Drug Discovery” Section of Biomedicines (ISSN: 2227-9059) publishes reviews and original peer-reviewed papers of a high scientific level covering all aspects of the biomedical use of natural compounds. Papers aim to review or report the discovery of novel natural compounds, novel medical or health uses of existing natural compounds, the bioactivities of natural compounds, pharmaceutical and nutraceutical formulations of natural compounds, new technology for natural compound extraction and purification, the pharmacology of natural compounds, combination therapy with natural compounds as supplements, and any new frontiers of natural compound research. Topics include, but are not limited to, the following: in vivo/in vitro bioactivity research, the chemical identification and characterization of bioactive natural compounds, the clinical study of natural compounds, the pharmaceutical formulation of natural compounds (including nano-formulation and prodrug formulation), targeted combination therapies (i.e., synergy between natural compounds and standard chemotherapy), preclinical and clinical pharmacology, the synthesis (chemical synthesis and biosynthesis) and modification of natural compounds, and advanced extraction as well as purification technology to improve yield, purity, and bioactivity.

You’re welcome to read the following papers:

1. “Natural Photosensitizers in Antimicrobial Photodynamic Therapy”
by Ece Polat and Kyungsu Kang
Biomedicines 2021, 9(6), 584; https://doi.org/10.3390/biomedicines9060584
Available online: https://www.mdpi.com/2227-9059/9/6/584

2. “Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs”
by Bruno Rizzuti, Fedora Grande, Filomena Conforti, Ana Jimenez-Alesanco, Laura Ceballos-Laita, David Ortega-Alarcon, Sonia Vega, Hugh T. Reyburn, Olga Abian and Adrian Velazquez-Campoy
Biomedicines 2021, 9(4), 375; https://doi.org/10.3390/biomedicines9040375
Available online: https://www.mdpi.com/2227-9059/9/4/375

3. “Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines”
by Bashir Lawal, Yen-Lin Liu, Ntlotlang Mokgautsi, Harshita Khedkar, Maryam Rachmawati Sumitra, Alexander T. H. Wu and Hsu-Shan Huang
Biomedicines 2021, 9(1), 92; https://doi.org/10.3390/biomedicines9010092
Available online: https://www.mdpi.com/2227-9059/9/1/92

4. “Antiviral Effects of Polyphenols from Marine Algae”
by Natalya N. Besednova, Boris G. Andryukov, Tatyana S. Zaporozhets, Sergey P. Kryzhanovsky, Ludmila N. Fedyanina, Tatyana A. Kuznetsova, Tatyana N. Zvyagintseva and Mikhail Yu. Shchelkanov
Biomedicines 2021, 9(2), 200; https://doi.org/10.3390/biomedicines9020200
Available online: https://www.mdpi.com/2227-9059/9/2/200

5. “Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota”
by Olga V. Averina , Elena U. Poluektova, Mariya V. Marsova and Valery N. Danilenko
Biomedicines 2021, 9(10), 1340; https://doi.org/10.3390/biomedicines9101340
Available online: https://www.mdpi.com/2227-9059/9/10/1340

6. “Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities”
by Jolita Stabrauskiene, Dalia M. Kopustinskiene, Robertas Lazauskas and Jurga Bernatoniene
Biomedicines 2022, 10(7), 1686; https://doi.org/10.3390/biomedicines10071686
Available online: https://www.mdpi.com/2227-9059/10/7/1686

7. “Molecular Mechanisms of Resistance to Immune Checkpoint Inhibitors in Melanoma Treatment: An Update”
by Sonja Vukadin, Farah Khaznadar, Tomislav Kizivat, Aleksandar Vcev and Martina Smolic
Biomedicines 2021, 9(7), 835; https://doi.org/10.3390/biomedicines9070835
Available online: https://www.mdpi.com/2227-9059/9/7/835

8. “Serum Inflammatory Biomarkers in the Diagnosis of Periprosthetic Joint Infections”
by Irene K. Sigmund, Stephan E. Puchner and Reinhard Windhager
Biomedicines 2021, 9(9), 1128; https://doi.org/10.3390/biomedicines9091128
Available online: https://www.mdpi.com/2227-9059/9/9/1128

9. “Curcumin and Radiotherapy Exert Synergistic Anti-Glioma Effect In Vitro”
by Vasiliki Zoi, Vasiliki Galani, Evrysthenis Vartholomatos, Natalia Zacharopoulou, Eftichia Tsoumeleka, Georgios Gkizas, Georgios Bozios, Pericles Tsekeris, Ieremias Chousidis, Ioannis Leonardos et al.
Biomedicines 2021, 9(11), 1562; https://doi.org/10.3390/biomedicines9111562
Available online: https://www.mdpi.com/2227-9059/9/11/1562

10. “Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers”
by Vasiliki Zoi, Vasiliki Galani, Pericles Tsekeris, Athanasios P. Kyritsis and George A. Alexiou
Biomedicines 2022, 10(2), 312; https://doi.org/10.3390/biomedicines10020312
Available online: https://www.mdpi.com/2227-9059/10/2/312

We would appreciate it if you would circulate the links of any papers that you find appealing to your network.

Submitting a Manuscript:
This Section is currently open for submissions. Papers may be submitted via the following link: https://susy.mdpi.com/user/manuscripts/upload/f17a01dbff7541081d1092edf09cd870?form%5Bjournal_id%5D=158.

Launching a Special Issue:
You have the opportunity to propose hot topics and edit a Special Issue together with experts in the field at the following link: https://www.mdpi.com/journalproposal/sendproposalspecialissue/biomedicines.

Joining the Editorial Board:
We are looking for active scholars who have an interest in and passion to help with the selection of submissions; please do not hesitate to get in touch (biomedicines@mdpi.com) if you are interested in joining the Editorial Board.

Biomedicines Editorial Office