
COVID-19 mRNA vaccines saved millions of lives during the pandemic crisis by efficiently protecting against the severe forms of the disease. However, they were much less efficient in protecting against the infection itself and viral transmission. Furthermore, the immunity induced by these vaccines proved to wane relatively rapidly. To understand these features and possibly improve the efficacy and safety of mRNA vaccines, it is critical to obtain insight into their action on the innate immune system.
During this webinar, we will first review the current knowledge on adjuvants included in protein-based vaccines and their action on the innate immune system. We will then discuss how lipid nanoparticles and nucleoside-modified mRNA—the two major components of currently approved mRNA vaccines—contribute to the activation of the innate immune system required for the induction of protective immunity. Finally, we will consider the consequences of this activation on the immune defenses against other pathogens through the phenomenon of trained immunity.
Date: 10 May 2023 at 10:00 a.m. CEST | 4:00 a.m. EST | 3:00 a.m. CST Asia
Webinar ID: 871 5675 7294
Register now for free!

Speaker/Presentation
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Time in CEST
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Time in EST
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Prof. Dr. Michel Goldman Chair Introduction
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10:00—10:05 a.m.
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4:00—4:05 a.m.
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Dr. Nathalie Garçon Lessons Learned from Vaccine Adjuvants
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10:05—10:35 a.m.
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4:05—4:35 a.m.
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Dr. Rein Verbeke The Adjuvant Properties of mRNA-LNP Vaccines
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10:35—11:05 a.m.
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4:35—5:05 a.m.
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Dr. Mihai Netea How to Leverage Trained Immunity?
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11:05—11:35 a.m.
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5:05—5:35 a.m.
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Q&A Session
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11:35—11:55 a.m.
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5:35—5:55 a.m.
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Prof. Michel Goldman Closing of Webinar
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11:55—12:00 p.m.
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5:55—6:00 a.m.
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Webinar Chairs and Keynote Speakers:
Prof. Dr. Michel Goldman (Chair), Institute for Interdisciplinary Innovation in healthcare, Université libre de Bruxelles, Brussels, Belgium
Dr. Nathalie Garçon (Co-Chair), N3J Consulting, Belgium
Dr. Rein Verbeke, 1 Ghent Research Group on Nanomedicines, Ghent University, Ghent, Belgium; 2 Cancer Research Institute Ghent (CRIG), Ghent, Belgium
Dr. Mihai Netea, 1 Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboudumc Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands; 2Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany
Relevant Special Issue:
“Learning from COVID-19 Vaccines”
Guest Editor: Prof. Dr. Michel Goldman
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