It is with profound sadness that we announce the passing of Prof. Dr. Pierre Chambon, a founding giant of modern molecular biology and pioneer of nuclear receptor research, on 5 May 2026, in Strasbourg, France, aged 95.
His influence is profound. While the Nobel Prize often favors single breakthroughs with clear attribution in a specific timeframe, Prof. Dr. Chambon’s impact was broad, systematic, and spanned decades. It cannot be reduced to “one discovery in one year”; his contributions far surpassed any single achievement.
Over his seven‑decade career, he reshaped molecular biology through landmark advances: the discovery of poly(ADP‑ribose), identification of eukaryotic RNA polymerases, definition of the nucleosome, co‑discovery of split genes, and characterization of enhancers. Most notably, he pioneered the nuclear receptor superfamily, transforming endocrinology, development, and medicine.
As a visionary institution builder, he founded IGBMC, Europe’s leading biomedical institute, and mentored generations of scientists. His work laid enduring foundations for life sciences and clinical applications.
We extend our deepest condolences to his family, colleagues, and the global scientific community.
