Ms. Sylvia Mangani holds a BSc in biochemistry and biotechnology from the University of Thessaly (2022, Larissa, Greece), where she initiated her research career as an undergraduate student in the Laboratory of Structural and Functional Biochemistry. She subsequently completed her joint MSc in applied biochemistry at the University of Patras (2025), focusing on the development of advanced three-dimensional cell culture models to investigate solid tumor dynamics, extracellular matrix remodeling, and epigenetic regulation. She is currently a PhD candidate in the Biochemistry, Biochemical Analysis, and Matrix Pathobiology research group of the Laboratory of Biochemistry, Department of Chemistry, University of Patras (Patras, Greece). Her research is focused on the extracellular matrix-mediated intercellular communication and epigenetic regulation in two- and three-dimensional breast cancer models. Her work has been presented at national and international scientific conferences and published in peer-reviewed journals, highlighting both the scientific rigor and translational relevance of her research.

The following is a short interview with Ms. Sylvia Mangani:

1. What initially inspired your research interest in this field?
My interest in this field emerged during my MSc studies, when I was first involved in an independent experimental project exploring how cellular microenvironment profoundly shapes cell behavior and disease progression. I became particularly intrigued by the concept that cancer is driven not only by genetic alterations within tumor cells, but also by dynamic interactions with the surrounding extracellular matrix and neighboring cells. Working with three-dimensional cell culture models further strengthened this interest, as these advanced culture models clearly demonstrated how strongly cellular behavior depends on spatial organization and mechanical cues. This experience deepened my curiosity about how microenvironmental signals regulate key processes such as intercellular communication, cellular adaptation, and epigenetic reprogramming during cancer progression. Ultimately, what inspired me most was the realization that understanding these complex interactions could lead to the development of more physiologically relevant experimental models and, potentially, more effective therapeutic strategies.

2. How did you first learn about this award, and what motivated you to apply?
I first learned about this award through my supervisor, who encouraged me to apply because it closely aligns with my research interests and career development goals. I was particularly motivated by the opportunity to attend the Matrix Biology Europe 2026 Conference in Finland, as it would allow me to present my work to an international audience and engage with leading researchers in extracellular matrix biology. I also saw it as a valuable opportunity to receive feedback on my research, broaden my scientific perspective, and build collaborations. Attending such a conference would further strengthen my communication skills, expand my professional network, and support my growth as an early-career researcher.

3. How do you feel about receiving this award?
I am truly honored and grateful to receive the Cancers Travel Award for 2025. This recognition is both inspiring and motivating, reaffirming my dedication to advancing research in this field. More than a personal milestone, I see this award as an invaluable opportunity to connect with the broader scientific community, exchange ideas, gain fresh perspectives, and grow professionally and personally. It encourages me to continue making meaningful contributions to cancer research and to pursue collaborations that can drive innovation and deepen our collective understanding.

4. What qualities do you believe are most essential for a young researcher today?
I believe that curiosity and perseverance are among the most essential qualities for a young researcher today. Science is often filled with uncertainty and setbacks, so resilience and commitment to continuous learning are crucial. Equally important is critical thinking, the ability to question assumptions, interpret data carefully, and approach problems from multiple angles. Adaptability and openness to collaboration are also vital, as modern research is increasingly interdisciplinary and constantly evolving. Above all, integrity and a genuine passion for discovery form the foundation of meaningful scientific progress, ensuring that research is both rigorous and driven by enthusiasm.

5. What advice would you give to early career researchers aiming to make an impact in oncology?
Early career researchers seeking to make an impact in oncology should focus on developing both scientific excellence and a clear sense of purpose. A strong foundation in experimental design, data analysis, and disease biology is essential, as impactful research is built on rigor, accuracy, and critical thinking. It is equally important to align research questions with unmet clinical needs. Work that is guided by clinical relevance has the greatest potential to translate into real-world benefit. Collaboration and openness to interdisciplinary approaches are also crucial, as oncology research increasingly relies on the integration of diverse expertise, and progress often arises from shared perspectives and collective effort. Seeking mentorship, engaging with the scientific community, and communicating findings effectively all contribute to professional growth and impact. Finally, resilience and integrity are fundamental. Progress in oncology is rarely immediate, and setbacks are an inherent part of research. Maintaining perseverance, ethical standards, and a long-term vision will enable early-career researchers to contribute in a sustained and meaningful way to the field.