Regulation of Hippocampal GABAergic Transmission by Fluoxetine and Its Metabolite Norfluoxetine
Abstract
:1. Introduction
2. Materials and Methods
2.1. Hippocampal Brain Slices
2.2. Single-Cell Electrophysiological Recordings
2.2.1. Recording of sIPSCs
2.2.2. Recording of GABA-Induced Currents
2.3. Data Analysis and Statistics
3. Results
3.1. Spontaneous GABAergic Synaptic Activity in CA1 Interneurons
3.2. Effects of Fluoxetine and Norfluoxetine on sIPSCs in Hippocampal Interneurons
3.3. Effects of Fluoxetine and Norfluoxetine on GABA-Induced Currents
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Vázquez-Gómez, E.; Hernández-Abrego, A.; Mejía-Piedras, J.; García-Colunga, J. Regulation of Hippocampal GABAergic Transmission by Fluoxetine and Its Metabolite Norfluoxetine. Receptors 2024, 3, 1-12. https://doi.org/10.3390/receptors3010001
Vázquez-Gómez E, Hernández-Abrego A, Mejía-Piedras J, García-Colunga J. Regulation of Hippocampal GABAergic Transmission by Fluoxetine and Its Metabolite Norfluoxetine. Receptors. 2024; 3(1):1-12. https://doi.org/10.3390/receptors3010001
Chicago/Turabian StyleVázquez-Gómez, Elizabeth, Andy Hernández-Abrego, Jassiel Mejía-Piedras, and Jesús García-Colunga. 2024. "Regulation of Hippocampal GABAergic Transmission by Fluoxetine and Its Metabolite Norfluoxetine" Receptors 3, no. 1: 1-12. https://doi.org/10.3390/receptors3010001