1. Introduction
Distal radius fractures are one of the most common upper extremity injuries, accounting for up to 2.5% of all emergency department visits with trends of increasing incidence [
1]. These injuries have a bimodal incidence, with elderly patients typically presenting after low energy injuries such as a fall from standing onto an outstretched hand, and younger patients presenting after higher energy injuries. Volar locked plating (VLP) has emerged as a common means of successfully surgically treating distal radius fractures. Surgical treatment of distal radius fractures offers a range of advantages over nonsurgical treatment, particularly when the fracture is comminuted or displaced. One of the primary benefits is the ability to achieve anatomic restoration, as open reduction allows precise realignment of fracture fragments. This precise alignment contributes to improved functional outcomes, reducing the risk of malunion or nonunion, and improving range of motion, strength, and grip function [
2]. Furthermore, surgical treatment of distal radius fractures can improve articular congruity which may decrease the risk of post-traumatic arthritis and long-term pain or functional deficits and allow for earlier mobilization and rehabilitation, often leading to a faster overall functional recovery.
As surgeons have gained expertise with locked volar plates, the indications for their use have continued to expand. Surgeons have begun to use locked volar plates for more complicated fracture patterns including intra-articular fractures, distal volar lunate facet/ulnar corner fracture fragments, and fractures with complex comminution [
3,
4]. However, there are significant complications that surgeons must be aware of, ranging from median nerve injuries and tendon irritation to infection and loss of reduction [
5,
6]. Previous reports demonstrate complication rates up to 39% [
5]. Of these, early loss of reduction plays a significant part in causing poor surgical outcomes, excessive healthcare expenses, and patient dissatisfaction. Despite the importance of hardware failure, understanding the factors that lead to early loss of reduction remains challenging.
The risk of hardware failure with VLP ranges from 2 to 15% depending on surgeon experience [
6,
7,
8]. In closed management of distal radius fractures, studies have explored how age, osteoporosis, Arbeitsgemeinschaft für Osteosynthesefragen (AO) classification, and initial loss of radial alignment all contribute to the risk of re-displacement after closed reduction [
9,
10,
11]. However, while early studies have emphasized technical factors such as plate and subchondral screw placement, there are few studies that explore the contributing factors and risks associated with loss of reduction in operatively treated fractures [
12,
13]. By better understanding how fracture patterns affect intraoperative alignment and loss of reduction, surgeons can identify which cases may be more susceptible to early failure and consider alternative treatment options such as combination plating or external fixation.
Multiple classification systems such as Frykman, Fernandez, universal, and AO have been developed in attempts to characterize the severity of distal radius fractures [
14,
15]. The AO classification has become popular due to its ease of use, high communicability, and improved interobserver reliability [
16]. The AO classification system provides a standardized language used to describe distal radius fractures, increasing the uniformity with which the severity of the fracture may be described (
Table 1). The simplicity and clarity with which the AO classification system communicates information has led to an increase in its utilization in clinical research and education. Though the AO classification does an effective job of communicating fracture patterns, its prognostic value is still debatable.
The AO classification system for distal radius fractures, although widely used, is not without its limitations. One of its key weaknesses is its complexity, with numerous fracture types and modifiers that can make it challenging for clinicians to quickly and accurately classify fractures, especially for those with less experience. This complexity can also result in interobserver variability, as different healthcare providers may classify the same fracture differently, leading to inconsistent treatment recommendations and outcomes. Moreover, the system relies on subjective judgment for certain fracture characteristics, such as comminution, further contributing to variation in reliability. The classification system may not account for all possible variations of distal radius fractures, and it does not consider patient-specific factors like age, comorbidities, or activity level, which can impact treatment. Additionally, it may not always adequately address the complex decision-making process for surgical treatment, as surgeons need to consider multiple factors beyond the classification, such as displacement. Lastly, while the system describes the fracture, it does not inherently guide prognosis or provide comprehensive data on long-term outcomes and complications associated with each fracture type. These limitations underscore the need for a careful and comprehensive approach when using the AO classification system for distal radius fractures.
There is evidence that worse AO fracture types (Group C fractures) may lead to an increased risk of loss of reduction in closed management [
17]. However, in operative treatment, its impact on restoration of normal radiographic parameters and early loss of reduction has yet to be studied. Understanding these correlations may allow for improved utility of the classification and more accurate preoperative counseling for patients.
During intraoperative fixation of distal radius fractures, restoration of anatomic distal radius parameters (as defined by radial height 10–13 mm, radial inclination 21–25 degrees, and 10 degrees of volar tilt) remains a common goal of surgery. However, the importance of radiographic restoration on functional outcomes is highly debated. Studies in small populations have found that mild variations in radiographic parameters correlate poorly with functional outcome [
18]. These studies raise concerns regarding restoration of “normal” parameters as a surrogate for successful surgical treatment.
Overall, the purpose of this study is to determine the impact of fracture pattern and severity, as determined by the AO classification system, on intraoperative restoration of radiographic anatomic parameters, early loss of reduction, and time to fracture union in operatively treated distal radius fractures. By better understanding how AO fracture type affects operative outcomes, the prognostic value of the classification may be notably improved.
2. Methods
After receiving institutional review board approval, we retrospectively identified all patients surgically treated for a distal radius fracture at a single safety net level I trauma center between 1 January 2014 and 31 December 2018 treated by two fellowship-trained hand surgeons. We performed a thorough retrospective chart review and radiographic review of all patients meeting our inclusion criteria.
2.1. Subjects
Adult patients (age 18 or older) with acute distal radius fractures treated surgically at a single level I Trauma institution with a minimum of a 6-week follow-up during the study period were included. Demographic information including sex, age, history of diabetes, tobacco use, and laterality were collected to analyze and account for possible confounders. Patients were excluded if they had a previous ipsilateral distal radius fracture, distal radius fractures treated non-surgically, an age of less than 18 years, those fractures treated by non-hand fellowship-trained surgeons, and patients with less than a 6-week postoperative follow-up. Patients with previous ipsilateral distal radius fractures were excluded as our aim was to determine which distal radius fractures were able to be restored back to normal radiographic parameters surgically, and we were unable to determine radiographic alignment in these patients prior to their most recent fracture met normal parameters.
2.2. Data Acquisition
Data were collected using retrospective chart and radiograph review. Radiographs were reviewed by two orthopedic residents to obtain AO classification of fracture at time of injury, immediate postoperative distal radius parameters (inclination, height, and volar tilt), and any early loss of reduction. Disagreement between reviewers was determined by the senior author, a fellowship-trained orthopedic hand surgeon. Restoration of radiographic parameters postoperatively was defined as radial height 8–13 mm, radial inclination 21–25 degrees, and volar tilt greater than or equal to 0 degrees [
19]. Early loss of reduction was defined as loss of these parameters or displacement of intra-articular fragments within 30 days post-operation. Radiographs are typically obtained at each visit until radiographic union is obtained, and visits are typically scheduled at 2, 4, 6, and 12 weeks post-operation. Wrist spanning bridge plates are typically removed 12 weeks after the index surgery. The postoperative course was reviewed to identify complications and time to radiographic healing. The final radiographic assessment was made at the determination of radiographic healing by the treating surgeon.
2.3. Statistical Analyses
Continuous data were tested for normality using the Shapiro–Wilks test; due to the data’s distribution the Mann–Whitney Wilcoxon, or Kruskal–Wallis was used to assess differences across the data. To test multiple comparisons, the Dwass–Steel–Critchlow–Fligner multiple comparison procedure was used. The Fisher’s exact test was used to assess all the categorical variables.
One-way analysis of variance (ANOVA) was used to determine the relationship between AO classification of distal radius fractures and postoperative radial height, tilt, and inclination, as well as complications. Chi-squared analysis was used to analyze the effect of AO classification on restoration of radiographic parameters and early loss of reduction. One-way ANOVA was also used to test for significant differences time to radiographic healing.
Statistical significance was considered p ≤ 0.05.
4. Discussion
The purpose of this study was to identify how fracture pattern and severity, as described by the AO classification, affect intraoperative fracture reduction as well as subsequent early loss of reduction and time to fracture union. While many studies have explored factors that lead to re-displacement in nonoperatively treated distal radius fractures, there is limited knowledge of the factors that contribute to loss of reduction in operatively treated fractures [
8]. This study adds to the utility of the AO classification by demonstrating that higher energy fracture types have worse restoration of anatomic parameters intra-operatively and increased time to fracture union; however, this does not correlate with a substantial difference in early hardware failure, loss of fracture reduction, or complications. Understanding this relationship can assist surgeons in establishing realistic expectations during surgery and in providing more accurate guidance to patients when establishing their postoperative expectations. This may make a significant impact on the evaluation of successful operative care in distal radius fractures, especially at higher volume centers that see a wider range of complex fracture types.
The significance of achieving proper anatomic alignment in distal radius fractures has been a subject of extensive debate in the existing literature. While some studies have shown that restoration of parameters such as ulnar variance and volar tilt can have an impact on patient grip strength and functional outcomes, other studies have shown no difference in range of motion, pain, and advanced patient functional questionnaires [
19,
20]. A recent study by Chung et al. demonstrated that in a database of 166 patients, precise restoration of distal radius anatomy did not make a significant functional impact [
18]. This study was performed on older patients, aged > 60, to assess if the increasing demands of a healthier and more active geriatric population are affecting outcomes after distal radius surgery. However, other studies evaluating the impact of anatomic restoration on function have found significant differences in outcomes such as in the disabilities of the arm, shoulder, and hand (DASH) questionnaire scores and grip strength. While different studies have highlighted various parameters as influential, multiple studies have highlighted ulnar variance and volar tilt as consistently important factors [
18,
20]. Ultimately, the impact of anatomic restoration remains debatable, especially due to a lack of studies with significant power in respect to higher energy fractures in younger populations. Although the importance of radiographic restoration remains questionable, it is important to understand the factors which may lead to inadequate reduction. Madsen et al. showed that in a database of 576 distal radius fractures treated with volar locked plating, operative treatment of very few fractures restored anatomic volar tilt and shortening of the distal radius was seen in as many as 9–22% of patients [
21].
This study adds to the literature by showing that fracture patterns, as determined by the AO classification, have a significant impact on the precision of surgical realignment. While radial inclination and height did not significantly vary between fracture types, volar tilt was more difficult to reproduce in higher energy fracture patterns with notable comminution. Comminution was found to be a negative predictor of anatomic postoperative alignment with decreased rates of restoration in both extra-articular and intra-articular fracture patterns. Partial articular fractures were found to be protective factors likely due to an intact column of articular bone. Ultimately, this shows that surgeons treating highly impacted distal radius fractures may reasonably expect to have difficulty restoring intraoperative alignment, specifically in relation to volar tilt. As discussed, the importance of precise restoration remains debatable with some studies suggesting no impact (especially in older patient populations) and others highlighting volar tilt and ulnar variance as important factors in grip strength and function. Either way, understanding how fracture patterns affect the difficulty of reduction provides surgeons with better tools to manage their intraoperative expectations and more adequately evaluate the technical success of distal radius surgery.
Hardware failure with subsequent loss of reduction is an uncommon but significant complication of operatively treated distal radius fractures. Loss of reduction can have a significant impact on patient outcome scores and the overall cost of care of these injuries as the rate of revision open reduction internal fixation or subsequent wrist salvage procedures are increased after initial failure. Quantifying the incidence of loss of reduction has remained difficult as there are no universal standards regarding what constitutes loss of reduction nor when reoperation is required. Retrospective studies of postoperative radiographs suggest that most distal radius fractures treated with VLP have some settling of the fracture postoperatively, though the rates of malalignment requiring revision remain low [
22]. This study shows that although fracture patterns do affect anatomical restoration of parameters, fracture type is not predictive of early loss of reduction within 30 days post-operation (
p = 0.164). Our overall rate of early loss of reduction, defined as <30 days, was 8.06% (34/422) which is in line with the rates reported in the literature. These findings add to the utility of the AO classification by showing that although certain fracture patterns may have worse anatomic restoration intraoperatively, this is not associated with early loss of fracture reduction. Other studies have emphasized technical factors such as screw placement/diameter and stabilization of the volar lunate/ulnar corner fragment in maintaining fracture reduction [
12,
23]. The underlying cause of fracture reduction loss postoperatively is likely related to these proposed factors more than fracture characteristics, such as comminution and articular involvement.
The AO classification has gained popularity in describing distal radius fractures due to its interobserver reliability and ease of communication. Our analysis of the effect of the AO classification on operative anatomic restoration and early loss of fracture reduction improves its utility. The effects of many variables such as type of fixation, obesity, and smoking have been analyzed to determine what factors influence patient satisfaction after distal radius surgery. However, the influence of fracture type has not been studied in high volume databases. In this study, fracture type was found to have a significant influence on the time to radiographic healing. On average, C type fractures took 1–2 weeks longer to heal radiographically compared to their lower energy counterparts. Our data suggest that higher energy fractures take longer to heal radiographically; however, based on previous small studies, this finding does not appear to have an effect on functional recovery as patients with C type fractures have adequate functional outcomes at long-term postoperative follow up after operative fixation with VLP [
24]. Future evaluations may be enhanced by further analysis of PROMs and grip strength comparisons by fracture type.
It is important to note that there are limitations to our study, including those inherent to a retrospective chart review. We chose to quantify early loss of reduction as <30 days from the date of surgery. While we recognize that this may not capture all malunions and ultimate loss of reduction, we chose to keep this short timeframe as we believe this better represents the impact of the fracture pattern and hardware adequacy compared to other factors such as patient activity, bone quality, ability to heal, and adherence to restrictions. Another limitation is the mixed treatment modalities, especially the use of additional bridge plates in C3 type distal radius fractures. Though the ability to restore alignment and maintain reduction may be influenced by a bridge plate, we believe that including all treatment modalities gives a better picture of the fracture patterns’ impact rather than the choice of hardware. We recognize that the choice of hardware remains surgeon-specific and may vary affecting the applicability of our findings. Lastly, as in any retrospective study, there are limitations which must be recognized including potential selection bias, data completeness, unidentified confounding variables, incomplete follow-up, and inability to measure or capture certain variables. These most significantly pertain to our evaluation of time to radiographic healing. However, we believe our high follow-up rate at 6 weeks (82%) and adequate rate of final follow-up (55%), especially at a safety net level 1 county trauma hospital, allow for adequate interpretation of the data in this study’s context.
The future direction of research regarding the applicability of the AO classification of distal radius fractures is likely to involve several key areas of investigation and improvement, including validation, predictive modeling, and creation of a treatment algorithm to guide surgeon decision making. Furthermore, future research focus on assessing and comparing the long-term outcomes of distal radius fractures classified using the AO system could provide insights into which fracture types/subtypes are associated with the best or worst functional and patient reported outcomes. Future research on the applicability of the AO classification of distal radius fractures is likely to be characterized by a combination of validation, refinement, data-driven decision making, and a focus on patient-centered care. The ultimate goal is to enhance the precision and effectiveness of fracture management while considering individual patient characteristics and preferences.