Is Metagenomics the Future Routine Diagnosis Tool for Brain Abscesses? About a Case
Abstract
:1. Introduction
2. Detailed Case Description
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Reference | Age | Sample | Active Antimicrobial Therapy Prior to Sampling | Culture Results | PCR Results | SMg Results | SMg Results Induced Change in Patient Management |
---|---|---|---|---|---|---|---|
Our case | 70-year old | Pus from brain abscess | Yes | Negative | 16S PCR: negative | Streptococcus anginosus, Fusobacterium nucleatum | Yes |
Hu et al., 2019 [16] | 2-month old | Pus from brain abscess | Yes | Bacteroides fragilis | NA | Bacteroides fragilis | Yes |
Hu et al., 2019 [16] | 5-year old | Pus from brain abscess | Yes | Streptococcus intermedius | NA | Streptococcus intermedius, Streptococus constellatus | Yes |
Hu et al., 2019 [16] | 10-year old | Pus from brain abscess | Yes | Negative | NA | Streptococcus intermedius | Yes |
Hu et al., 2019 [16] | 13-year old | Pus from brain abscess | Yes | Negative | NA | Prevotella oris, Fusobacterium nucleatum, Streptococcus intermedius | No |
Ma et al., 2021 [17] | 75-year old | CSF | No prior to culture, Yes prior to SMg | Negative | NA | Prevotella denticola, Fusobacterium nucleatum | Yes |
Zhou et al., 2021 [18] | 50-year old | CSF | No prior to culture, Yes prior to SMg | Negative | NA | Nocardia farcinica | Yes |
Huang et al., 2021 [20] | 61-year old | Pus from brain abscess | Yes | Negative (Ziehl-Neelsen staining positive) | NA | Nocardia asiatica | Yes |
Deng et al., 2020 [21] | 27-year old | Pus from brain abscess | Yes | Negative | NA | Prevotella loescheii | Yes |
Yang et al., 2022 [23] | 58-year old | CSF | Yes | Positive | NA | Nocardia farcinica | Yes |
Zhang et al., 2022 [24] | 65-year old | CSF | Yes | Negative | NA | Porphyromonas gingivalis | Yes |
Li et al., 2022 [25] | 49-year old | CSF | Yes | Positive | NA | Nocardia brevicatena | No |
Gao et al., 2022 [26] | 30-year old | CSF | Yes | Positive | NA | Scedosporium boydii | No |
Yao et al., 2022 [27] | 67-year old | CSF | Yes | Negative | NA | Streptococcus intermedia Nocardia asiatica | Yes |
Chen et al., 2022 [28] | 66-year old | CSF | Yes | Negative | NA | Streptococcus suis | Yes |
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Lars, W.; Lamoureux, C.; Picard, J.; Rodriguez, C.; Beauruelle, C.; Quaesaet, L.; Héry-Arnaud, G.; Ansart, S.; Coste, A. Is Metagenomics the Future Routine Diagnosis Tool for Brain Abscesses? About a Case. Biologics 2023, 3, 335-341. https://doi.org/10.3390/biologics3040018
Lars W, Lamoureux C, Picard J, Rodriguez C, Beauruelle C, Quaesaet L, Héry-Arnaud G, Ansart S, Coste A. Is Metagenomics the Future Routine Diagnosis Tool for Brain Abscesses? About a Case. Biologics. 2023; 3(4):335-341. https://doi.org/10.3390/biologics3040018
Chicago/Turabian StyleLars, William, Claudie Lamoureux, Jérémy Picard, Christophe Rodriguez, Clémence Beauruelle, Luc Quaesaet, Geneviève Héry-Arnaud, Séverine Ansart, and Anne Coste. 2023. "Is Metagenomics the Future Routine Diagnosis Tool for Brain Abscesses? About a Case" Biologics 3, no. 4: 335-341. https://doi.org/10.3390/biologics3040018