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Case Report

Plasma Renin Concentration in Critically Ill COVID-19 Patients

by
Gabriele Melegari
1,*,
Lucia Veronesi
2,
Jessica Maccieri
1,
Francesco Ponzetta
1,
Suela Osmenaj
3 and
Alberto Barbieri
3
1
Department of Anaesthesia and Intensive Care, Azienda Ospedaliero Universitaria di Modena, Via Del Pozzo 71, 41215 Modena, Italy
2
School of Surgery, Università degli Studi di Modena and Reggio Emilia, Via Del Pozzo 71, 41125 Modena, Italy
3
School of Anaesthesia and Intensive Care, Università degli Studi di Modena and Reggio Emilia, Via Del Pozzo 71, 41125 Modena, Italy
*
Author to whom correspondence should be addressed.
BioMed 2021, 1(2), 94-98; https://doi.org/10.3390/biomed1020008
Submission received: 23 August 2021 / Revised: 3 October 2021 / Accepted: 4 October 2021 / Published: 7 October 2021
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Abstract

Investigations of plasma renin concentration as a marker of organ perfusion in several intensive care settings have shown a significant correlation between its increase and a lack of perfusion in critical tissues, especially in septic patients. Castillo et al. proposed that activation of the non-canonical pathway of the renin–angiotensin–aldosterone system could improve cardiovascular homeostasis under COVID-19. During the first wave of COVID-19, we preliminarily enrolled a small cohort of subjects admitted to the Intensive Care Unit with a diagnosis of COVID-19 and acute respiratory distress syndrome. Their plasma renin value was measured in the first 24 h (T0), in the following 72 h (T1), and after one week (T2). In eight patients, we observed a higher plasma renin concentration—patients with difficulty weaning and in non-survivors. This is a preliminary observation. The variation of plasma renin levels in a septic condition is known, but settings such as COVID-19 infection have recently been investigated, showing a correlation with angiotensin-converting enzyme 2 receptor expression and functionality; in the near future, it will be interesting to have more data about its variation and value in COVID-19 patients.
Keywords: plasma renin; COVID-19; ICU biomarker plasma renin; COVID-19; ICU biomarker

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MDPI and ACS Style

Melegari, G.; Veronesi, L.; Maccieri, J.; Ponzetta, F.; Osmenaj, S.; Barbieri, A. Plasma Renin Concentration in Critically Ill COVID-19 Patients. BioMed 2021, 1, 94-98. https://doi.org/10.3390/biomed1020008

AMA Style

Melegari G, Veronesi L, Maccieri J, Ponzetta F, Osmenaj S, Barbieri A. Plasma Renin Concentration in Critically Ill COVID-19 Patients. BioMed. 2021; 1(2):94-98. https://doi.org/10.3390/biomed1020008

Chicago/Turabian Style

Melegari, Gabriele, Lucia Veronesi, Jessica Maccieri, Francesco Ponzetta, Suela Osmenaj, and Alberto Barbieri. 2021. "Plasma Renin Concentration in Critically Ill COVID-19 Patients" BioMed 1, no. 2: 94-98. https://doi.org/10.3390/biomed1020008

APA Style

Melegari, G., Veronesi, L., Maccieri, J., Ponzetta, F., Osmenaj, S., & Barbieri, A. (2021). Plasma Renin Concentration in Critically Ill COVID-19 Patients. BioMed, 1(2), 94-98. https://doi.org/10.3390/biomed1020008

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