An Overview of Selected Material Properties in Finite Element Modeling of the Human Femur

Round 1

Reviewer 1 Report

As stated in the title, the study provides an overview of selected material properties in finite-element modeling of the human femur. I find interesting the space given to the different components of the femur, including the bone marrow.

I think the article is well written and the subject of the study interesting, so I think the article can contribute to the literature.

I have only a few points for authors which require modification:

1) The sentences in the abstract about the importance of specific finite detail modeling of the human body should be stated in the introduction. Likewise, the aim of the study should be better clarified in the introduction.

2) The methodology used by the authors to obtain their data should be explained more thoroughly.

3) Where is Figure 3?

4) The conclusions are repeated twice.

Thank you.

Author Response

Q1) The sentences in the abstract about the importance of specific finite detail modeling of the human body should be stated in the introduction. Likewise, the aim of the study should be better clarified in the introduction.

• 1-Regarding your request, I add a sentence about aim of this research. Moreover, there are some sentences in introduction to show goal of this study.

Q2) The methodology used by the authors to obtain their data should be explained more thoroughly.

• 2-Thanks for your detailed tip. I added some sentences about methodology of each examination. I wanted to make a brief review and did not explain more in my first version of manuscript.

Q3) Where is Figure 3?

• 3-It was a typo. There are 2 figures. Thanks for your tip.

Q4) The conclusions are repeated twice.

• 4-Thanks for your tip. I edited and rewrite it.

Reviewer 2 Report

There are several important notes related to the review paper entitled: "An overview of selected material properties in Finite-Element Modeling of the Human Femur" :

1. In designing the model, the characteristics of the ideal human femur should be targeted so that it will become a reference in developing the model. Meanwhile, Table 13 shows the characteristics of the FE model, which are different from the findings of other researchers. Would the findings obtained on the FE model fit better and be more natural for the human femur?

2. In table 9, there is a wide variation in the results of rheology, indentation, and cavitation measurements in marrow samples 1-9. How is the average calculated? This data becomes crucial in the analysis of this review. The chance of bias is enormous.

3. The use of terminology at the beginning must be written in full, as in the term FE design (line 49), STL file (line 52), DHS, CS (line 52)

4. Lines 54-55 contain the sentence, "Therefore, researchers are unable to 54 design a model of the human with design three". What does this sentence mean in this section? The author must correct the sentences in the paragraph.

5. Lines 77-82 need to be clarified. The author must reconstruct several sentences to become a coherent and meaningful statement.

6. The arrangement of references in citations to all parts of the manuscript must be consistent by writing them in order of year and then alphabetically if the year of publication is the same.

7. The author must combine Tables 12 and 14 into one unit

8. At the conclusion, there is a repetition of sentences, namely lines 264-267, with lines 267-271

9. Typology errors, such as writing morrow on line 179 and several other sections, are still common.

Author Response

Q1. In designing the model, the characteristics of the ideal human femur should be targeted so that it will become a reference in developing the model. Meanwhile, Table 13 shows the characteristics of the FE model, which are different from the findings of other researchers. Would the findings obtained on the FE model fit better and be more natural for the human femur?

• 1-Yes, all of these physical and mechanical properties were examined on the human femur. This research completely differs from others. Moreover, it helps other researchers to implement FE analysis with the right material properties. We reviewed all these properties and choose the average of these amounts.

Q2. In table 9, there is a wide variation in the results of rheology, indentation, and cavitation measurements in marrow samples 1-9. How is the average calculated? This data becomes crucial in the analysis of this review. The chance of bias is enormous.

• 2-Thanks for your tip. It was a simple average method (total of each section except tolerance/9). It is important to choose one amount in material properties of FE analysis.

Q3. The use of terminology at the beginning must be written in full, as in the term FE design (line 49), STL file (line 52), DHS, CS (line 52)

• 3-I have edited these abbreviations.

Q4. Lines 54-55 contain the sentence, "Therefore, researchers are unable to 54 design a model of the human with design three". What does this sentence mean in this section? The author must correct the sentences in the paragraph.

• 4-It means that most of the researchers import CT scan file to Slicer software and convert it to STL files of the femur bone. It was used for 3D printing and FE analysis. However, it does not have a design tree to edit the model of a human femur. I clarified my sentence with this explanation.

Q5. Lines 77-82 need to be clarified. The author must reconstruct several sentences to become a coherent and meaningful statement.

• 5-It was clarified if you read the explanation by watching fig. 2. However, I added some sentences according to your request for explaining more.

Q6. The arrangement of references in citations to all parts of the manuscript must be consistent by writing them in order of year and then alphabetically if the year of publication is the same.

• 6-I arranged the citation as you requested.

Q7. The author must combine Tables 12 and 14 into one unit

• 7-I combined them.

Q8. At the conclusion, there is a repetition of sentences, namely lines 264-267, with lines 267-271

• 8-Thanks for this tip. I have edited it.

Q9. Typology errors, such as writing morrow on line 179 and several other sections, are still common.

• 9-Thanks for this tip. I have found and edit them.

Round 2

Reviewer 1 Report

The authors have addressed all my concerns. Thank you.

Reviewer 2 Report

The revised version of the manuscript entitled "An overview of selected material properties in Finite-Element Modeling of the Human femur" has undergone significant improvements. It is also supported by replacing some more precise points to clarify the sentence. In addition, the author has clarified some issues very well. They have also answered some of the questions or comments discussed in previous reviews, although not all of them.

Furthermore, I recommend accepting this revised version of the manuscript.