Platelet Concentration and Platelet/Lymphocyte Ratio as Prognostic Indicators in Luminal Breast Cancer
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Characteristics of the Patients
3.2. Establishment of Cutoff—ROC Curves
3.3. Prognostic Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Relapse | Death | |||||
---|---|---|---|---|---|---|
Characteristic | N (%) | Without 46 (63.9) | With 26 (36.1) | Without 59 (81.9) | With 13 (18.1) | Total 72 (100) |
Age at diagnosis (72) | 47.0 ± 12.2 | 46.1 ± 12.6 | 47.3 ± 12.8 | 44.2 ± 9.88 | ||
≤40 year | 32 (44) | 19 (41.3) | 13 (50.0) | 25 (42.4) | 7 (53.8) | 32 (44.4) |
40 to 60 years | 30 (42) | 20 (43.5) | 10 (38.5) | 25 (43.5) | 5 (38.5) | 30 (41.7) |
≥60 years | 10 (14) | 7 (15.2) | 3 (11.5) | 9 (15.3) | 1 (7.7) | 10 (13.9) |
Tumoral grade (72) | ||||||
I | 12 (16.7) | 11 (23.9) | 1 (3.8) * | 12 (20.3) | 0 (0.0) | 12 (16.7) |
II | 35 (48.6) | 24 (52.2) | 11 (42.3) * | 29 (49.2) | 6 (46.2) | 35 (48.6) |
III Clinical staging (71) | 25 (34.7) | 11 (23.9) | 14 (53.8) * | 18 (30.5) | 7 (53.8) | 25 (34.7) |
T1 | 27 (37.5) | 23 (50.0) | 4 (15.4) ** | 26 (44.8) | 1 (7.7) * | 27 (38.0) |
T2 | 29 (40.3) | 19 (41.3) | 10 (38.5) ** | 24 (41.4) | 5 (38.5) * | 29 (40.8) |
T3/T4 | 15 (20.8) | 4 (8.7) | 11 (42.3) ** | 8 (13.8) | 7 (53.8) * | 15 (21.2) |
N0 | 36 (50.0) | 32 (69.6) | 4 (15.4) ** | 33 (56.9) | 3 (23.1) * | 36 (50.7) |
N1 | 20 (27.8) | 12 (26.1) | 8 (30.8) ** | 16 (27.6) | 4 (30.8) * | 20 (28.2) |
N2/N3 | 15 (20.8) | 2 (4,4) | 13 (50.0) ** | 9 (15.5) | 6 (46.1) * | 15 (21.1) |
Treatment | ||||||
Radiotherapy | 62/69 (86.1) | 39 (62.9) | 23 (37.1) | 49 (87.5) | 13 (100) | 62/69 (89.8) |
Chemotherapy | 16/61 (22.2) | 27 (44.3) | 18 (29.5) ** | 36 (69.2) | 9 (100) | 45/61 (73.8) |
Histology (72) | ||||||
Ductal | 63 (87.5) | 41 (65.1) | 22(34.9) | 52 (82.5) | 11 (17.4) | 63 (87.5) |
Lobular | 9 (12.5) | 5 (55.5) | 4 (44.4) | 7 (77.8) | 2 (22.2) | 9 (12.5) |
Immunohistochemistry (72) | ||||||
Ki 67 < 14 | 45/72 (62.5) | 33 (73.3) | 12 (26.7) | 39 (66.1) | 6 (46.2) | 45 (62.5) |
Ki 67 > 14 | 27/72 (37.5) | 14 (51.8) | 13 (48.2) | 20 (33.9) | 7 (53.8) | 27 (37.5) |
Variable | N | Platelet (×103/mm3) | p | |
---|---|---|---|---|
<297 | >297 | |||
Age at diagnosis | 72 | 43 (100) | 29 (100) | 0.35 |
≤40 years | 32 | 21 (48.8) | 11 (37.9) | |
40 to 60 years | 30 | 18 (41.9) | 12 (41.1) | |
≥60 years | 10 | 4 (9.3) | 6 (20.7) | |
Median ± std deviation | 45.2 ± 11.7 | 49.1 ± 13.0 | 0.19 | |
Tumoral grade | 72 | 43 (100) | 29 (100) | 0.08 |
I | 12 | 10 (23.3) | 2 (6.9) | |
II | 35 | 22 (51.2) | 13 (44.8) | |
III | 25 | 11 (25.6) | 14 (48.3) | |
Clinical staging | 71 | 42 (100) | 29 (100) | |
T1 | 27 | 21 (50.0) | 6 (20.7) | 0.01 |
T2 | 29 | 16 (38.1) | 13 (44.8) | |
T3 | 7 | 4 (9.5) | 3 (10.3) | |
T4 | 8 | 1 (2.4) | 7 (24.1) | |
N0 | 71 | 24 (57.1) | 12 (41.4) | 0.01 |
N1 | 20 | 15 (35.7) | 5 (17.2) | |
N2 | 8 | 3 (7.1) | 5 (17.2) | |
N3 | 7 | 0 (0.0) | 7 (24.1) | |
Relapse | 72 | 43 (100) | 29 (100) | 0.04 |
No | 46 | 32 (69.6) | 14 (30.4) | |
Yes | 26 | 11 (42.3) | 15 (57.7) | |
Death | 72 | 43 (100) | 29 (100) | 0.04 |
No | 59 | 39 (66.1) | 20 (33.9) | |
Yes | 13 | 4 (30.8) | 9 (69.2) | |
Radiotherapy | 69 | 40 (100) | 29 (100) | 0.69 |
No | 7 | 5 (12.5) | 2 (6.9) | |
Yes | 62 | 35 (87.5) | 27 (93.1) | |
Chemotherapy | 61 | 39 (100) | 22 (100) | 0.44 |
No | 16 | 12 (30.8) | 4 (18.2) | |
Yes | 45 | 27 (69.2) | 18 (81.8) | |
Histology | 72 | 43 (100) | 29 (100) | 0.73 |
Ductal | 63 | 37 (86.0) | 26 (89.7) | |
Lobular | 9 | 6 (14.0) | 3 (10.3) | |
Leukocyte | 72 | 6124 ± 2057 | 7355 ± 1986 | 0.01 |
Neutrophil | 72 | 3647 ± 1419 | 4605 ± 1635 | 0.01 |
Lymphocyte | 72 | 1788 ± 743 | 1969 ± 650 | 0.29 |
Monocyte | 72 | 483 ± 176 | 576 ± 154 | 0.02 |
6 years DFS (95% CI) | 72 | 60.9 (54.7–67.2) | 54.0 (46.3–61.6) | 0.04 |
6 years OS (95% CI) | 72 | 119.1 (113.6–124.6) | 127.4 (110.1 ± 144.7) | 0.08 |
Variable | N | PLR | p | Platelet (×103/mm3) | p | SII | p | |||
---|---|---|---|---|---|---|---|---|---|---|
<191.5 | >191.5 | <279 | >279 | <431.3 | >431.3 | |||||
Age at diagnosis | 72 | 46 (100) | 26 (100) | 0.36 | 35 (100) | 37 (100) | 0.74 | 21 (100) | 51 (100) | 0.78 |
≤40 years | 25 (48.1) | 7 (35.0) | 17 (48.6) | 15 (40.5) | 10 (47.6) | 22 (43.1) | ||||
40 to 60 years | 19 (36.5) | 11 (55.0) | 14 (40.0) | 16 (43.2) | 9 (42.9) | 21 (41.2) | ||||
≥60 years | 8 (15.4) | 2 (10.0) | 4 (11.4) | 6 (16.2) | 2 (9.5) | 8 (15.7) | ||||
Tumoral grade | 72 | 52 (100) | 20 (100) | 0.61 | 35 (100) | 37 (100) | 0.12 | 21 (100) | 51 (100) | 0.82 |
I | 10 (19.2) | 2 (10.0) | 7 (20.0) | 5 (13.5) | 4 (19.0) | 8 (15.7) | ||||
II | 24 (46.2) | 11 (55.0) | 20 (57.1) | 15 (40.5) | 9 (42.9) | 26 (51.0) | ||||
III | 18 (34.6) | 7 (35.0) | 8 (22.9) | 17 (45.9) | 8 (38.1) | 17 (33.3) | ||||
Clinical staging | 71 | 51 (100) | 20 (100) | 34 (100) | 37 (100) | 20 (100) | 51 (100) | |||
T1 | 20 (39.2) | 7 (35.0) | 0.09 | 17 (50.0) | 10 (27.0) | 0.02 | 7 (35.0) | 20 (39.2) | 0.38 | |
T2 | 24 (47.1) | 5 (25.0) | 14 (41.2) | 15 (40.5) | 11 (55.0) | 18 (35.3) | ||||
T3 | 3 (5.9) | 4 (20.0) | 3 (8.8) | 4 (10.8) | 1 (5.0) | 6 (11.8) | ||||
T4 | 4 (7.8) | 4 (20.0) | 0 (0.0) | 8 (21.6) | 1 (5.0) | 7 (13.7) | ||||
N0 | 71 | 24 (47.1) | 12 (60.0) | 0.54 | 24 (61.8) | 15 (40.5) | 0.04 | 11 (55.0) | 25 (49.0) | 0.34 |
N1 | 14 (27.5) | 6 (30.0) | 10 (29.4) | 10 (27.0) | 7 (35) | 13 (25.5) | ||||
N2 | 7 (13.7) | 1 (5.0) | 3 (8.8) | 5 (13.5) | 2 (10.0) | 6 (11.8) | ||||
N3 | 6 (11.8) | 1 (5.0) | 0 (0.0) | 7 (18.9) | 0 (0.0) | 7 (13.7) | ||||
Relapse | 72 | 52 (100) | 20 (100) | 0.88 | 35 (100) | 37 (100) | 0.12 | 21 (100) | 51 (100) | 0.26 |
No | 34 (65.4) | 12 (60.0) | 26 (74.3) | 20 (54.1) | 16 (76.2) | 30 (58.8) | ||||
Yes | 18 (34.6) | 8 (40.0) | 9 (25.7) | 17 (45.9) | 5 (23.8) | 21 (41.2) | ||||
Death | 72 | 52 (100) | 20 (100) | 0.04 | 35 (100) | 37 (100) | 0.02 | 21 (100) | 51 (100) | 0.01 |
No | 46 (88.5) | 13 (65.0) | 33 (94.3) | 26 (70.3) | 21 (100) | 38 (74.5) | ||||
Yes | 6 (11.5) | 7 (35.0) | 2 (5.7) | 11 (29.7) | 0 (0.0) | 13(25.5) | ||||
Histology | 72 | 52 (100) | 20 (100) | 0.70 | 35 (100) | 37 (100) | 1.00 | 21 (100) | 51 (100) | 0.71 |
Ductal | 46 (88.5) | 17 (85.0) | 31 (88.6) | 32 (86.5) | 18 (85.7) | 45 (88.2) | ||||
Lobular | 6 (11.5) | 3 (15.0) | 4 (11.4) | 5 (13.5) | 3 (14.3) | 6 (11.8) | ||||
Leukocyte | 72 | 7048 ± 2060 | 5508 ± 1829 | 0.00 | 6426 ± 2050 | 6804 ± 2166 | 0.45 | 5839 ± 2405 | 6942 ± 1900 | 0.04 |
Neutrophil | 72 | 4210 ± 1541 | 3574 ± 1595 | 0.12 | 3941 ± 1314 | 4121 ± 1795 | 0.63 | 2973 ± 1408 | 4470 ± 1430 | 0.00 |
Lymphocyte | 72 | 2095 ± 679 | 1252 ± 308 | 0.00 | 1779 ± 789 | 1937 ± 623 | 0.35 | 2137 ± 900 | 1746 ± 584 | 0.03 |
Monocyte | 72 | 531 ± 175 | 496 ± 170 | 0.44 | 495 ± 185 | 545 ± 159 | 0.22 | 508 ± 210 | 526 ± 157 | 0.68 |
Platelet (×103/mm3) | 72 | 266 ± 63 | 321 ± 81 | 0.00 | 222 ± 32 | 337 ± 52 | 0.00 | 242 ± 49 | 297 ± 74 | 0.03 |
DFS | OS | |||||||
---|---|---|---|---|---|---|---|---|
Univariable | Multivariable | Univariable | Multivariable | |||||
p | HR Ratio (95% CI) | p | HR Ratio (95% CI) | p | HR Ratio (95% CI) | p | HR Ratio (95% CI) | |
Age | 0.79 | 0.996 (0.64–0.30) | ---- | ---- | 0.15 | 0.961 (0.91–4.02) | ---- | ---- |
Grade 3 (vs. Grade 1–2) | 0.01 | 2.754 (1.27–5.98) | 0.53 | 1.346 (0.53–3.42) | 0.23 | 1.992 (0.64–6.18) | ---- | ---- |
T2 (vs. T1) | 0.12 | 2.520 (0.79–8.04) | 0.53 | 1.497 (0.43–5.20) | 0.17 | 4.516 (0.53–38.74) | 0.18 | 4.761 (0.50–45.64) |
T3 (vs. T1) | 0.01 | 8.118 (2.16–30.48) | 0.13 | 3.221 (0.72–14.40) | 0.02 | 14.337(1.48–148.32) | 0.37 | 2.984 (0.27–32.97) |
T4 (vs. T1) | 0.00 | 8.622 (2.41–30.80) | 0.19 | 2.713 (0.61–12.18) | 0.03 | 11.686 (1.21–113.03) | 0.54 | 2.206 (0.18–27.16) |
N1 (vs. N0) | 0.02 | 4.390 (1.32–14.59) | 0.05 | 3.474 (1.00–12.21) | 0.22 | 2.533 (0.57–11.33) | 0.13 | 4.139 (0.65–26.52) |
N2 (vs. N0) | 0.00 | 18.497 (5.29–64.64) | 0.00 | 11.255 (2.84–44.63) | 0.14 | 3.810 (0.63–22.88) | 0.03 | 21.012 (1.42–311.08) |
N3 (vs. N0) | 0.00 | 11.838 (3.30–42.42) | 0.01 | 6.396 (1.45–28.18) | 0.02 | 6.561 (1.31–32.81) | 0.01 | 23.234 (2.08–259.71) |
Platelets (×103/mm3) > 279 (vs. <279) | 0.04 | 2.241 (1.03–4.89) | 0.65 | 1.307 (0.42–4.07) | 0.04 | 4.788 (1.05–21.93) | 0.58 | 1.638 (0.28–9.52) |
PLR > 191.5 (vs. <191.5) | 0.58 | 1.263 (0.549–2.905) | ---- | ----- | 0.01 | 4.402 (1.39–13.94) | 0.00 | 16.156 (2.83–109.25) |
KI67 Pos (vs. Neg) | 0.16 | 1.728 (0.80–3.73) | ---- | ---- | 0.38 | 1.663 (0.53–5.19) | ---- | ---- |
Histology Lobular (vs. Ductal) | 0.53 | 1.410 (0.49–4.09) | ---- | ---- | 0.64 | 1.440 (0.31–6.58) | ---- | ---- |
Platelet (×103 mm3) | 0.27 | 1.003 (0.99–1.01) | ---- | ---- | 0.22 | 1.004 (1.00–1.01) | ---- | ---- |
Leukocyte | 0.11 | 1.000 (1.00–1.00) | ---- | ---- | 0.29 | 1.000 (1.00–1.00) | ---- | ---- |
Neutrophil | 0.25 | 1.000 (1.00–1.00) | ---- | ---- | 0.43 | 1.000 (1.00–1.00) | ---- | ---- |
Lymphocyte | 0.14 | 1.000 (1.00–1.00) | ---- | ---- | 0.17 | 0.999 (1.00–1.00) | ---- | ---- |
Monocyte | 0.17 | 1.002 (1.00–1.00) | ---- | ---- | 0.93 | 1.000 (1.00–1.01) | ---- | ---- |
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Rönnau, A.D.R.O.; Berto, M.D.; Bica, C.G.; Alves, R.V.; Rotta, L.N. Platelet Concentration and Platelet/Lymphocyte Ratio as Prognostic Indicators in Luminal Breast Cancer. J. Mol. Pathol. 2023, 4, 15-27. https://doi.org/10.3390/jmp4010002
Rönnau ADRO, Berto MD, Bica CG, Alves RV, Rotta LN. Platelet Concentration and Platelet/Lymphocyte Ratio as Prognostic Indicators in Luminal Breast Cancer. Journal of Molecular Pathology. 2023; 4(1):15-27. https://doi.org/10.3390/jmp4010002
Chicago/Turabian StyleRönnau, Angela Della’Santa Rubio O., Maiquidieli Dal Berto, Claudia Giuliano Bica, Rafael Vargas Alves, and Liane Nanci Rotta. 2023. "Platelet Concentration and Platelet/Lymphocyte Ratio as Prognostic Indicators in Luminal Breast Cancer" Journal of Molecular Pathology 4, no. 1: 15-27. https://doi.org/10.3390/jmp4010002