Plasmonic Biosensors Based on Deformed Graphene
, Mohsen Heidari 1, Nik Humaidi bin Nik Zulkarnine 2 and Michael Taeyoung Hwang 3,*
Round 1
Reviewer 1 Report
This is an interesting work on Plasmonic biosensors based on deformed graphene, where the authors used biaxially crumpled graphene to improve the sensitivity and FOM of RI sensor.
-As it is shown in the result section, biaxially crumpled graphene exhibits two plasmon resonances, please clarify the advantages of having two resonances from sensing point of view.
-"The biaxially crumpled structure on PS substrate exhibited a sensitivity of 4990 nm/RIU and FOM of 20, whereas the uniaxial structure had a sensor sensitivity of 4350 nm/RIU and FOM of 43". Higher FOM resulted from uniaxial structure while the author concluded "Thus, the overall sensor sensitivity and FOM for the biaxially crumpled graphene were higher than those obtained using uniaxially crumpled structures and flat graphene-based sensors"
- Based on figure 4, as crumpled widths and heights change the response of the sensor varies in a way that the number of resonances is changing, please clarify the effect of these resonances on the sensing applications which introduces errors.
-The functionality of the proposed RI sensor was only validated through numerical simulations. Please clarify the practical implementation of the proposed sensor and experimental validation.
Author Response
Please see the attachment.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
The manuscript entitled "Plasmonic biosensors based on deformed graphene" has presented a new RI sensor based on plasmonic resonances in biaxially crumpled graphene structures for operation in the mid-IR region. The authors have significantly contributed to evaluating the sensing performance of the proposed RI sensor in terms of sensitivity and figure-of-merit and very well compared it with that of a uniaxially crumpled graphene-based plasmonic sensor. Overall, this is a clear, concise, and well-written manuscript. The introduction is relevant and statics-based. Sufficient information about the previous study findings is presented for readers to follow the present study rationale and procedures. The methods are generally appropriate, and the results are precise and convincing the view. The authors make a systematic contribution to the research literature in this area of investigation; however, some recent studies should be cited and included in the current manuscript. Though the manuscript is written well, some modifications in a few sentences and references could improve it. Overall, the manuscript could be accepted after the brief inclusion of comments.
1. Introduction- Lines 31-34- Refractive index (RI) sensing is.......... the mid-infrared (mid-IR) range.
Comment: Authors must cite relevant references for using RI sensing in these applications.
2. The authors have explained that RI sensing is of significant interest for real-time biosensing applications. Please specify or include one more sentence defining RI sensing promiscuous role in these applications, as the manuscript is focused on biosensor use. This will drive the reader's interest in developing RI-based sensors.
2-Author: Line 37-38- Slight variations in the RI....resonant wavelength.
Comment: Please specify the range of the distinct shift in resonant wavelength upon varying the RI.
3-Author: Material and methods Section:
Comment: In lines 242-243, The authors have given the semiclassical Drude model. Please specify the temperature you used for the simulation and include that in your material and method section.
4-Comment: In the conclusion section, authors have described the potential role of highly sensitive RI sensors in developing high-performance biosensing platforms; however, can you please describe their promising functions in wide biomedical applications? Specifically in a human health monitoring application.
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
