Oncocytic Adenoma in a Pediatric Patient: A Case Report and Literature Review
Abstract
1. Introduction
2. Case Presentation
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
EU-TIRADS | European Thyroid Imaging and Reporting Data System |
FNA | Fine-needle aspiration |
FT3 | Free tri-iodothyronine |
FT4 | Free thyroxine |
OA | Oncocytic adenoma |
OC | Oncocytic carcinoma |
SIAPEC | Italian Society of Anatomic Pathology and Diagnostic Cytopathology |
TgAb | Anti-thyroglobulin antibodies |
TPOAb | Thyroid peroxidase antibodies |
TSH | Thyroid-stimulating hormone |
References
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Thyroid Function Test | Result | Reference Range |
---|---|---|
FT3 | 3.4 pg/mL | 2.3–4.2 |
FT4 | 1.09 ng/dL | 0.8–1.6 |
TSH | 1.81 mIU/mL | 0.4–3.5 |
Calcitonin | <0.5 pg/mL | <6.4 |
TPOAb | 30 U/mL | <60 |
TgAb | <10 U/mL | <4.5 |
Study | Age (Years)/Gender | Nodule Size | Presentation | FNA Cytology | Treatment | Outcome |
---|---|---|---|---|---|---|
Current case | 13/Female | 26 × 16 mm | Enlarging neck mass | Bethesda IV (follicular neoplasm with oncocytic features) | Hemithyroidectomy | No recurrence |
Green et al., 2020 [19] | 18/Female | 5.9 × 4.4 × 3.7 cm | Incidentally identified neck mass, mild hyperthyroid symptoms | Rare clusters of cells with cytological atypia, negative for nuclear features of papillary carcinoma | Left hemithyroidectomy | No recurrence |
Kochummen et al., 2017 [20] | 14/Female | Bilateral nodules (sizes not specified) | Enlarging thyroid nodules | Not specified | Sequential hemithyroidectomy | No recurrence |
Bremer et al., 2007 [21] | 12/Female | 20 mm | Palpable thyroid nodule | Suspicious for follicular neoplasm | Hemithyroidectomy | No recurrence |
Roggli et al., 1979 [22] 1 | 22/Female | Multiple nodules (largest: 4 cm) | Neck mass 18 years after medulloblastoma treatment | Not specified | Subtotal thyroidectomy (95%) | No recurrence (8.5-month follow-up) |
Nagamachi et al., 1973 [23] | 12/Female (Twin 1) | Left lobe: single cystic tumor (~egg-sized); right lobe: three nodules (~10 mm each) | Enlarging cervical mass | Not specified | Local removal (First surgery), hemithyroidectomy (Second surgery) | No recurrence (13-year follow-up) |
Nagamachi et al., 1973 [23] | 12/Female (Twin 2) | Left lobe: 1 cm nodule; right lobe: 3 cm cystic nodule | Enlarging cervical mass | Not specified | Local removal (First surgery), hemithyroidectomy (Second surgery) | No recurrence (13-year follow-up) |
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Paparella, R.; Bellone, G.; Rizza, L.; Veccia, N.; Ricci, G.; Calvani, M.; Scommegna, S. Oncocytic Adenoma in a Pediatric Patient: A Case Report and Literature Review. Endocrines 2025, 6, 22. https://doi.org/10.3390/endocrines6020022
Paparella R, Bellone G, Rizza L, Veccia N, Ricci G, Calvani M, Scommegna S. Oncocytic Adenoma in a Pediatric Patient: A Case Report and Literature Review. Endocrines. 2025; 6(2):22. https://doi.org/10.3390/endocrines6020022
Chicago/Turabian StylePaparella, Roberto, Giulia Bellone, Laura Rizza, Norman Veccia, Gabriele Ricci, Mauro Calvani, and Salvatore Scommegna. 2025. "Oncocytic Adenoma in a Pediatric Patient: A Case Report and Literature Review" Endocrines 6, no. 2: 22. https://doi.org/10.3390/endocrines6020022
APA StylePaparella, R., Bellone, G., Rizza, L., Veccia, N., Ricci, G., Calvani, M., & Scommegna, S. (2025). Oncocytic Adenoma in a Pediatric Patient: A Case Report and Literature Review. Endocrines, 6(2), 22. https://doi.org/10.3390/endocrines6020022