Ovarian Rejuvenation Using Autologous Platelet-Rich Plasma
1
Department of Obstetrics and Gynecology, School of Medicine, International University of Health and Welfare, Narita, Chiba 286-8686, Japan
2
Phoenix ART Clinic, Shibuya, Tokyo 151-0051, Japan
*
Author to whom correspondence should be addressed.
Endocrines 2021, 2(1), 15-27; https://doi.org/10.3390/endocrines2010002
Received: 20 November 2020
/
Revised: 29 December 2020
/
Accepted: 5 January 2021
/
Published: 7 January 2021
Advanced maternal age is associated with the natural oocyte depletion, leading to low oocyte yield, high infertility treatment cancellation rates, and eventual decreases in pregnancy rates. Various innovative interventions have been introduced to improve the outcome of infertility treatment for aging patients. Numerous published data demonstrated that early follicle development was regulated by intraovarian growth factors through autocrine or paracrine mechanisms. Platelet-rich plasma (PRP), a plasma fraction of peripheral blood with a high concentration of platelets, has been implemented in regenerative medicine in the last decade. The plasma contains a variety of growth factors that were suggested to be able to enhance angiogenesis regeneration and the cell proliferation process. The initial report showed that an intraovarian injection of PRP improved the hormonal profile and increased the number of retrieved oocytes in patients with diminished ovarian reserve. Subsequently, several studies with larger sample sizes have reported that this approach resulted in several healthy live births with no apparent complications. However, the use of ovarian PRP treatment needs to be fully investigated, because no randomized controlled trial has yet been performed to confirm its efficacy.
View Full-Text
Keywords:
add on treatment; diminished ovarian reserve; platelet-rich-plasma; poor responders; premature-ovarian-insufficiency
▼
Show Figures
Graphical abstract
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
MDPI and ACS Style
Vo, T.K.C.; Tanaka, Y.; Kawamura, K. Ovarian Rejuvenation Using Autologous Platelet-Rich Plasma. Endocrines 2021, 2, 15-27. https://doi.org/10.3390/endocrines2010002
AMA Style
Vo TKC, Tanaka Y, Kawamura K. Ovarian Rejuvenation Using Autologous Platelet-Rich Plasma. Endocrines. 2021; 2(1):15-27. https://doi.org/10.3390/endocrines2010002
Chicago/Turabian StyleVo, Tuyen Kim Cat, Yuka Tanaka, and Kazuhiro Kawamura. 2021. "Ovarian Rejuvenation Using Autologous Platelet-Rich Plasma" Endocrines 2, no. 1: 15-27. https://doi.org/10.3390/endocrines2010002
Find Other Styles
