Novel Study of SARS-CoV-2 RNA in Post-Reperfusion Liver Biopsies after Transplantation Using COVID-19-Positive Donor Allografts
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Donors
3.2. Recipients
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Donor Characteristics | n = 20 |
---|---|
Age (years), mean ± SD | data |
Days from diagnosis of COVID-19, mean ± SD | 4.0 ± 3.1 |
Expedited placement, n (%) | 7 (35%) |
Recipient Characteristics | n = 20 |
Age (years), mean ± SD | 54.1 ± 10.3 |
Male, n (%) | 7 (35%) |
BMI, mean ± SD | 26.8 ± 3.8 |
MELD, mean ± SD | 21.2 ± 8.7 |
Retransplant, n (%) | 2 (10%) |
COVID-19 vaccination | 20 (100%) |
Boosted (>2 doses), n (%) | 12 (60%) |
Complete (2 doses), n (%) | 8 (40%) |
Outcomes | n (%) |
---|---|
COVID-19 RNA Present on Post-Reperfusion Biopsy | 2 (10%) |
Post-Operative Day 7 Nasopharyngeal RT-PCR COVID-19 Testing (Positive Result) | 0 |
Early Allograft Dysfunction | 2 (10%) |
Biliary Complications | 0 |
Deep Vein Thrombosis | 0 |
Respiratory Complications | 4 (20%) |
Vascular Complications | 1 (5%) |
30-Day Graft Survival | 20 (100%) |
30-Day Patient Survival | 20 (100%) |
1-Year Patient Survival | 19 (95%) |
Median survival | 685.5 days [IQR: 669.7–733.5] |
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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Whitrock, J.N.; Carter, M.M.; Price, A.D.; Delman, A.M.; Pratt, C.G.; Wang, J.; Sharma, D.; Quillin, R.C., III; Shah, S.A. Novel Study of SARS-CoV-2 RNA in Post-Reperfusion Liver Biopsies after Transplantation Using COVID-19-Positive Donor Allografts. Transplantology 2024, 5, 46-50. https://doi.org/10.3390/transplantology5010005
Whitrock JN, Carter MM, Price AD, Delman AM, Pratt CG, Wang J, Sharma D, Quillin RC III, Shah SA. Novel Study of SARS-CoV-2 RNA in Post-Reperfusion Liver Biopsies after Transplantation Using COVID-19-Positive Donor Allografts. Transplantology. 2024; 5(1):46-50. https://doi.org/10.3390/transplantology5010005
Chicago/Turabian StyleWhitrock, Jenna N., Michela M. Carter, Adam D. Price, Aaron M. Delman, Catherine G. Pratt, Jiang Wang, Divya Sharma, Ralph C. Quillin, III, and Shimul A. Shah. 2024. "Novel Study of SARS-CoV-2 RNA in Post-Reperfusion Liver Biopsies after Transplantation Using COVID-19-Positive Donor Allografts" Transplantology 5, no. 1: 46-50. https://doi.org/10.3390/transplantology5010005
APA StyleWhitrock, J. N., Carter, M. M., Price, A. D., Delman, A. M., Pratt, C. G., Wang, J., Sharma, D., Quillin, R. C., III, & Shah, S. A. (2024). Novel Study of SARS-CoV-2 RNA in Post-Reperfusion Liver Biopsies after Transplantation Using COVID-19-Positive Donor Allografts. Transplantology, 5(1), 46-50. https://doi.org/10.3390/transplantology5010005