Polygenic Embryo Risk Scores: A Survey of Public Perception
Abstract
1. Introduction
2. Methods
Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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[All] | N | |
---|---|---|
N = 633 | ||
Gender: | 633 | |
Female | 318 (50.2%) | |
Male | 315 (49.8%) | |
Age (y): | 633 | |
18–29 | 113 (17.9%) | |
30−44 | 192 (30.3%) | |
45−60 | 166 (26.2%) | |
>60 | 162 (25.6%) | |
US Region | 626 | |
Midwest: ND, SD, NE, KS, MO, IA, MN, WI, IL, IN, MI, and OH | 135 (21.6%) | |
Northeast: ME, NH, VT, MA, CT, RI, NY, PA, and NJ | 125 (20.0%) | |
South: TX, OK, AR, LA, MS, AL, TN, KT, WV, DC, VA, MD, DE, NC, SC, GA, and FL | 219 (35.0%) | |
West: MT, WY, CO, NM, AZ, UT, NZ, ID, WA, OR, CA, AK, and HI | 147 (23.5%) | |
Approximate household income (USD): | 620 | |
20,000 or less | 62 (10.0%) | |
20,001−40,000 | 106 (17.1%) | |
40,001−60,000 | 118 (19.0%) | |
60,001−80,000 | 89 (14.4%) | |
80,001−100,000 | 97 (15.6%) | |
100,001−150,000 | 89 (14.4%) | |
More than 150,001 | 59 (9.52%) | |
Marital status: | 630 | |
Married/civil union | 336 (53.3%) | |
Never married | 146 (23.2%) | |
Separated | 14 (2.22%) | |
Widowed | 23 (3.65%) | |
Divorced | 59 (9.37%) | |
In long-term relationship | 52 (8.25%) | |
Religion: | 626 | |
Atheist/Agnostic | 125 (20.0%) | |
Buddhism | 16 (2.56%) | |
Christian non-Catholic | 225 (35.9%) | |
Christian Catholic | 160 (25.6%) | |
Hindu | 19 (3.04%) | |
Jewish | 23 (3.67%) | |
Muslim | 12 (1.92%) | |
Other | 46 (7.35%) | |
Political party affiliation: | 624 | |
Democrat | 263 (42.1%) | |
Libertarian | 41 (6.57%) | |
None of the above | 103 (16.5%) | |
Republican | 151 (24.2%) | |
Other | 66 (10.6%) | |
Race: | 633 | |
White or Caucasian | 430 (67.9%) | |
American Indian or Alaska Native | 40 (6.32%) | |
Asians | 73 (11.5%) | |
Black or African American | 55 (8.69%) | |
Hispanic or Latino | 62 (9.79%) | |
Middle Eastern | 15 (2.37%) | |
Native Hawaiian or Pacific Islander | 3 (0.47%) | |
Number of children: | 624 | |
0 | 224 (35.9%) | |
1 | 111 (17.8%) | |
2 | 169 (27.1%) | |
3+ | 120 (19.2%) | |
If 0, do you want children in the future? | 228 | |
I am not sure | 51 (22.4%) | |
No | 95 (41.7%) | |
Yes | 82 (36.0%) | |
Do you personally know anyone who used infertility treatments? | 626 | |
No | 324 (51.8%) | |
Yes | 302 (48.2%) | |
Do you personally know anyone who has had infertility? | 627 | |
No | 249 (39.7%) | |
Yes | 378 (60.3%) | |
Is it important to you to have a child free of disease? | 627 | |
I do not know | 120 (19.1%) | |
No | 110 (17.5%) | |
Yes | 397 (63.3%) | |
If you were undergoing IVF, how much would you pay for PGT-P? (Embryo biopsy costs around USD 200 per embryo) (USD): | 630 | |
200−500 per embryo | 261 (41.4%) | |
500−1000 per embryo | 95 (15.1%) | |
1000−2000 per embryo | 30 (4.76%) | |
More than 2000 per embryo | 21 (3.33%) | |
I would not pay for PGT-P | 223 | |
Who should be able to use PGT-P? | 627 | |
Anyone | 333 (53.1%) | |
No one | 59 (9.41%) | |
Patients who are using donor egg or donor sperm (not their own) to create embryos | 96 (15.3%) | |
Patients with a personal or family history of certain diseases | 139 (22.2%) | |
Data were summarized using counts and percentages. Respondents were allowed to choose more than one race as appropriate. |
It Is the Perfect Idea. |
---|
I do not have any concerns. |
No objection if parents want it. |
I have no concerns about this. It falls within the rights of the parent(s) and is truly none of my |
business. |
As someone who has gone through IVF, I don’t see any problem with this kind of testing. I |
think people should stop trying to dictate the medical treatments others have access to, |
especially if they are safe. |
No concerns, except the cost. |
I do not care; it should be 100% allowed. |
It is eugenics. |
The information gained will be misused. |
I do not know enough info about the accuracy and safety. |
My only concern would be for the embryo; only a brief explanation is provided. |
Unknown consequences such as an insurance company not paying for the pregnancy if they |
do not like the test results. |
Disagree | Neutral | Agree | OR | 95% CI | p | |
---|---|---|---|---|---|---|
N = 60 | N = 234 | N = 339 | ||||
Age (y): | ||||||
<45 | 34 (7.28%) | 167 (35.8%) | 266 (57.0%) | Reference | ||
≥45 | 26 (15.7%) | 67 (40.4%) | 73 (44.0%) | 0.68 | 0.47–0.98 | 0.038 |
Gender: | ||||||
Female | 33 (10.4%) | 133 (41.8%) | 152 (47.8%) | Reference | ||
Male | 27 (8.57%) | 101 (32.1%) | 187 (59.4%) | 1.05 | 0.76–1.45 | 0.777 |
Religion: | ||||||
Christian non-Catholic | 30 (13.3%) | 82 (36.4%) | 113 (50.2%) | Reference | ||
Atheist/Agnostic | 7 (5.60%) | 36 (28.8%) | 82 (65.6%) | 1.93 | 1.21–3.10 | 0.006 |
Buddhism | 3 (18.8%) | 6 (37.5%) | 7 (43.8%) | 0.29 | 0.10–0.89 | 0.030 |
Christian Catholic | 12 (7.50%) | 63 (39.4%) | 85 (53.1%) | 0.87 | 0.58–1.31 | 0.503 |
Hindu | 1 (5.26%) | 8 (42.1%) | 10 (52.6%) | 0.81 | 0.31–2.08 | 0.657 |
Jewish | 1 (4.35%) | 8 (34.8%) | 14 (60.9%) | 2.07 | 0.88–4.85 | 0.096 |
Muslim | 0 (0.00%) | 4 (33.3%) | 8 (66.7%) | 1.18 | 0.35–3.96 | 0.791 |
Other | 5 (10.9%) | 23 (50.0%) | 18 (39.1%) | 0.83 | 0.44–1.57 | 0.570 |
Political party affiliation: | ||||||
Democrat | 19 (7.22%) | 90 (34.2%) | 154 (58.6%) | Reference | ||
Libertarian | 4 (9.76%) | 16 (39.0%) | 21 (51.2%) | 0.50 | 0.27–0.93 | 0.029 |
None of the above | 11 (10.7%) | 47 (45.6%) | 45 (43.7%) | 0.96 | 0.60–1.54 | 0.864 |
Other | 9 (13.6%) | 24 (36.4%) | 33 (50.0%) | 0.94 | 0.62–1.44 | 0.777 |
Republican | 16 (10.6%) | 54 (35.8%) | 81 (53.6%) | 0.89 | 0.51–1.54 | 0.666 |
Number of children: | ||||||
0 | 15 (6.70%) | 72 (32.1%) | 137 (61.2%) | Reference | ||
1 | 9 (8.11%) | 34 (30.6%) | 68 (61.3%) | 0.83 | 0.52–1.33 | 0.442 |
2 | 18 (10.7%) | 65 (38.5%) | 86 (50.9%) | 0.81 | 0.52–1.24 | 0.323 |
3+ | 17 (14.2%) | 58 (48.3%) | 45 (37.5%) | 0.63 | 0.40–1.01 | 0.057 |
US Region: | ||||||
Midwest | 18 (13.3%) | 48 (35.6%) | 69 (51.1%) | Reference | ||
Northeast | 9 (7.20%) | 44 (35.2%) | 72 (57.6%) | 0.84 | 0.51–1.39 | 0.497 |
South | 21 (9.29%) | 86 (38.1%) | 119 (52.7%) | 0.92 | 0.59–1.43 | 0.710 |
West | 12 (8.16%) | 56 (38.1%) | 79 (53.7%) | 0.87 | 0.53–1.41 | 0.565 |
Level of education: | 1.24 | 1.05–1.45 | 0.009 | |||
Some high school or less | 1 (5.00%) | 4 (20.0%) | 15 (75.0%) | |||
High school diploma or GED | 11 (7.75%) | 71 (50.0%) | 60 (42.3%) | |||
Technical or associate degree | 15 (12.0%) | 46 (36.8%) | 64 (51.2%) | |||
Bachelor’s degree | 18 (8.57%) | 76 (36.2%) | 116 (55.2%) | |||
Graduate or professional degree | 14 (10.6%) | 34 (25.8%) | 84 (63.6%) | |||
Approximate household income (USD): | 0.95 | 0.86–1.05 | 0.290 | |||
20,000 or less | 2 (3.23%) | 28 (45.2%) | 32 (51.6%) | |||
20,001−40,000 | 8 (7.55%) | 48 (45.3%) | 50 (47.2%) | |||
40,001−60,000 | 10 (8.47%) | 42 (35.6%) | 66 (55.9%) | |||
60,001−80,000 | 9 (10.1%) | 18 (20.2%) | 62 (69.7%) | |||
80,001−100,000 | 13 (13.4%) | 33 (34.0%) | 51 (52.6%) | |||
100,001−150,000 | 10 (11.2%) | 35 (39.3%) | 44 (49.4%) | |||
More than 150,001 | 6 (10.2%) | 22 (37.3%) | 31 (52.5%) | |||
Know anyone who had infertility: | ||||||
No | 21 (8.43%) | 119 (47.8%) | 109 (43.8%) | Reference | ||
Yes | 39 (10.3%) | 112 (29.6%) | 227 (60.1%) | 1.23 | 0.88–1.74 | 0.230 |
Essential to have a disease-free child: | ||||||
No | 21 (19.1%) | 45 (40.9%) | 44 (40.0%) | Reference | ||
I don’t know | 19 (15.8%) | 54 (45.0%) | 47 (39.2%) | 1.16 | 0.68–1.98 | 0.588 |
Yes | 20 (5.04%) | 131 (33.0%) | 246 (62.0%) | 2.41 | 1.55–3.77 | <0.001 |
Perceived safety of PGT-P | −0.64 (0.65) | −0.17 (0.39) | 0.23 (0.59) | 7.37 | 5.27–10.30 | <0.001 |
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Share and Cite
Peyser, A.; Brogan, C.; Zimmerman, L.; Goldman, R.H. Polygenic Embryo Risk Scores: A Survey of Public Perception. Reprod. Med. 2025, 6, 19. https://doi.org/10.3390/reprodmed6030019
Peyser A, Brogan C, Zimmerman L, Goldman RH. Polygenic Embryo Risk Scores: A Survey of Public Perception. Reproductive Medicine. 2025; 6(3):19. https://doi.org/10.3390/reprodmed6030019
Chicago/Turabian StylePeyser, Alexandra, Cailey Brogan, Lilli Zimmerman, and Randi H. Goldman. 2025. "Polygenic Embryo Risk Scores: A Survey of Public Perception" Reproductive Medicine 6, no. 3: 19. https://doi.org/10.3390/reprodmed6030019
APA StylePeyser, A., Brogan, C., Zimmerman, L., & Goldman, R. H. (2025). Polygenic Embryo Risk Scores: A Survey of Public Perception. Reproductive Medicine, 6(3), 19. https://doi.org/10.3390/reprodmed6030019