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Expression of Wilm’s Tumor Gene (WT1) in Endometrium with Potential Link to Gestational Vascular Transformation

Pathology, New York Presbyterian - Brooklyn Methodist Hospital, 506 6th St., Brooklyn, NY 11215, USA
Reprod. Med. 2020, 1(1), 17-31; https://doi.org/10.3390/reprodmed1010003
Received: 16 March 2020 / Revised: 24 April 2020 / Accepted: 29 April 2020 / Published: 30 April 2020
Background: Wilm’s tumor 1 gene (WT1) is a transcription factor with versatile cellular functions in embryonic development, the maintenance of adult tissue functions, and regeneration. WT1 is known to be regulated by progesterone and it is abundantly expressed in endometrium, but its function is unclear. Design: in this observational and descriptive study, WT1 expression was detected by immunohistochemical staining in endometrium of various physiological and pathological conditions. Result: WT1 was detected in endometrial stromal cells and vascular smooth muscle cells, in both proliferative and secretory phases of menstrual cycles. WT1 appeared increased in vascular smooth muscle cells in spiral artery in early pregnancy and it was also detected in regenerative endothelial cells and smooth muscle cells in decidual vasculopathy at term. WT1 expression appeared decreased in endometrial stromal cells in adenomyosis (endometriosis). Conclusion: WT1 potentially links the hormonal effects on endometrial decidualization and may play a role in gestational vascular transformation during pregnancy and restoration after pregnancy. View Full-Text
Keywords: WT1 gene; endometrium; decidual vasculopathy; spiral artery remodeling; regeneration; steroid hormones WT1 gene; endometrium; decidual vasculopathy; spiral artery remodeling; regeneration; steroid hormones
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MDPI and ACS Style

Zhang, P. Expression of Wilm’s Tumor Gene (WT1) in Endometrium with Potential Link to Gestational Vascular Transformation. Reprod. Med. 2020, 1, 17-31. https://doi.org/10.3390/reprodmed1010003

AMA Style

Zhang P. Expression of Wilm’s Tumor Gene (WT1) in Endometrium with Potential Link to Gestational Vascular Transformation. Reproductive Medicine. 2020; 1(1):17-31. https://doi.org/10.3390/reprodmed1010003

Chicago/Turabian Style

Zhang, Peilin. 2020. "Expression of Wilm’s Tumor Gene (WT1) in Endometrium with Potential Link to Gestational Vascular Transformation" Reprod. Med. 1, no. 1: 17-31. https://doi.org/10.3390/reprodmed1010003

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