Methoxyflurane for Relief of Procedural Pain in Burn Patients: A Prospective Single-Centre Evaluation Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Statement of Ethics
2.3. Eligibility Criteria
2.4. Study Site
2.5. Intervention
2.6. Data Collection
2.7. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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n = 12 | |
Patient characteristics | |
Age, years | 56 (50–68) |
Sex, male | 8 (67%) |
BMI #, kg/m2 | 26.5 (22.8–28.2) |
ASA classification | |
ASA II | 7 (58%) |
ASA III | 5 (42%) |
Burn related characteristics | |
Percentage of total burn surface area, % | 10.5 (4.5–19.2) |
Days since burn injury, days | 22 (17–34) |
Days since last operation, days | 6 (5–7) |
Pain level before procedure % | 35 (18–50) |
Procedure duration, minutes | 44 (34–56) |
Ongoing pain treatment | |
Oral analgesics | |
Paracetamol, 1 g × 2–4 | 12 (100%) |
Gabapentin, 300–600 mg × 2–3 | 10 (83%) |
Ibuprofen, 400 mg × 2–3 | 4 (33%) |
Morphine ¤ | 8 (67%) |
Others ¥ | 4 (33%) |
Intravenous | |
Morphine ¤ | 2 (17) |
95% CI | |||
Primary outcome | |||
Maximal pain during the procedure % | 60 (37–80) | ||
Secondary outcomes | |||
Procedure related outcomes | |||
Patient satisfaction % | 96 (69–100) | ||
Nurse-assessed pain level % | 57 (2–6]) | ||
Patient movement | 1 (8%) | ||
Serious adverse events and reactions | 0 (0%) | 0–24% | |
Adverse events | |||
During the procedure ¤ | 1 (8%) | 1–35% | |
1 week after the procedure $ | 1 (8%) | 1–35% | |
Before | After | ||
Physiologic changes | |||
Oxygen saturation, % | 98 (97–99) | 99 (98–100) | |
Pulse, beats/min | 92 (72–99) | 89 (73–96) | |
MAP §, mmHg | 106 (96–112) | 97 (87–109) | |
Lowest saturation during procedure, % | 96 (94–98) |
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Creutzburg, A.; Vestergaard, M.R.; Pape, P.; Hjelmdal, C.; Rangatchew, F.; Holmgaard, R.; Rasmussen, L.S. Methoxyflurane for Relief of Procedural Pain in Burn Patients: A Prospective Single-Centre Evaluation Study. Eur. Burn J. 2022, 3, 780-787. https://doi.org/10.3390/ebj3040047
Creutzburg A, Vestergaard MR, Pape P, Hjelmdal C, Rangatchew F, Holmgaard R, Rasmussen LS. Methoxyflurane for Relief of Procedural Pain in Burn Patients: A Prospective Single-Centre Evaluation Study. European Burn Journal. 2022; 3(4):780-787. https://doi.org/10.3390/ebj3040047
Chicago/Turabian StyleCreutzburg, Andreas, Martin R. Vestergaard, Pernille Pape, Caroline Hjelmdal, Filip Rangatchew, Rikke Holmgaard, and Lars S. Rasmussen. 2022. "Methoxyflurane for Relief of Procedural Pain in Burn Patients: A Prospective Single-Centre Evaluation Study" European Burn Journal 3, no. 4: 780-787. https://doi.org/10.3390/ebj3040047
APA StyleCreutzburg, A., Vestergaard, M. R., Pape, P., Hjelmdal, C., Rangatchew, F., Holmgaard, R., & Rasmussen, L. S. (2022). Methoxyflurane for Relief of Procedural Pain in Burn Patients: A Prospective Single-Centre Evaluation Study. European Burn Journal, 3(4), 780-787. https://doi.org/10.3390/ebj3040047