Different Mechanisms in Doxorubicin-Induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations
Abstract
:1. Introduction
1.1. Dox-Induced Cardiotoxicity (DIC)
1.2. Intercalation of DNA and Topoisomerase II Inhibition
1.3. NADPH Oxidases, Nitric Oxide Synthases, and Xanthine Oxidase
1.4. Antioxidants in Dox-Induced Cardiotoxicity
1.5. Peroxisomes in Dox-Induced Cardiotoxicity
1.6. Sirtuins Deacetylate Dox-Induced Cardiotoxicity
1.7. Dox Impairs Autophagy
1.8. Dox Induces Sarcoplasm Leakage
1.9. Dox-Induced Endotheliotoxicity (DIE)
1.10. The Endothelium
1.11. Endothelial Dysfunction
1.12. Dox-Induced Endothelial Dysfunction, Endotheliotoxicity, and Cardiotoxicity
1.13. Breast Cancer Genes 1 and 2
1.14. Breast Cancer Gene, Doxorubicin, and Cardiovascular Limitations, Implications, and Prospects
2. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviation
References
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Nguyen, H.C.; Frisbee, J.C.; Singh, K.K. Different Mechanisms in Doxorubicin-Induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations. Hearts 2024, 5, 54-74. https://doi.org/10.3390/hearts5010005
Nguyen HC, Frisbee JC, Singh KK. Different Mechanisms in Doxorubicin-Induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations. Hearts. 2024; 5(1):54-74. https://doi.org/10.3390/hearts5010005
Chicago/Turabian StyleNguyen, Hien C., Jefferson C. Frisbee, and Krishna K. Singh. 2024. "Different Mechanisms in Doxorubicin-Induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations" Hearts 5, no. 1: 54-74. https://doi.org/10.3390/hearts5010005
APA StyleNguyen, H. C., Frisbee, J. C., & Singh, K. K. (2024). Different Mechanisms in Doxorubicin-Induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations. Hearts, 5(1), 54-74. https://doi.org/10.3390/hearts5010005