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Open AccessReview

The Evolving Role of Mucosal Histology in the Evaluation of Pediatric Functional Dyspepsia: A Review

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Division of Gastroenterology, Hepatology, and Nutrition, Children’s Mercy Kansas City, 2401 Gillham Road, Kansas City, MI 64108, USA
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Division of Developmental and Behavioral Sciences, Children’s Mercy Kansas City, 2401 Gillham Road, Kansas City, MI 64108, USA
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Author to whom correspondence should be addressed.
Gastrointest. Disord. 2019, 1(1), 176-190; https://doi.org/10.3390/gidisord1010013
Received: 18 December 2018 / Accepted: 4 January 2019 / Published: 9 January 2019
Although not required to establish the diagnosis, endoscopy with mucosal biopsy is commonly performed in the evaluation of children with dyspepsia. Traditionally, esophagogastroduodenoscopy (EGD) has been performed in children with abdominal pain to identify pathology or conversely, to “rule-out” organic disease in order to establish a diagnosis of FD. In this review, we discuss the current diagnostic yield of endoscopically-obtained biopsies in identifying disease in children and adolescents with dyspepsia including an expanded discussion of common histologic diagnoses where clinical significance has not been definitively established. In turn, we discuss the transition of endoscopy from a search for disease to a search for biologic contributors to symptom generation, while considering the growing evidence linking non-diagnostic mucosal inflammation to FD, specifically mast cells and eosinophils. View Full-Text
Keywords: abdominal pain; functional dyspepsia; endoscopy; mast cells; eosinophils abdominal pain; functional dyspepsia; endoscopy; mast cells; eosinophils
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Friesen, C.A.; Colombo, J.M.; Schurman, J.V. The Evolving Role of Mucosal Histology in the Evaluation of Pediatric Functional Dyspepsia: A Review. Gastrointest. Disord. 2019, 1, 176-190.

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