Next Article in Journal
The Impact of on-Call Work for Partners’ Sleep, Relationship Quality and Daytime Functioning
Previous Article in Journal
Sleep in Hospitalized Patients
Article Menu

Export Article

Open AccessReview

Sleep Modelling across Physiological Levels

1
School of Physics, University of Sydney, Sydney 2006, NSW, Australia
2
Center of Excellence for Integrative Brain Function, University of Sydney, Sydney 2006, NSW, Australia
3
Charles Perkins Center, University of Sydney, Sydney 2006, NSW, Australia
Clocks & Sleep 2019, 1(1), 166-184; https://doi.org/10.3390/clockssleep1010015
Received: 20 December 2018 / Revised: 23 February 2019 / Accepted: 25 February 2019 / Published: 4 March 2019
  |  
PDF [955 KB, uploaded 12 March 2019]
  |  

Abstract

Sleep and circadian rhythms are regulated across multiple functional, spatial and temporal levels: from genes to networks of coupled neurons and glial cells, to large scale brain dynamics and behaviour. The dynamics at each of these levels are complex and the interaction between the levels is even more so, so research have mostly focused on interactions within the levels to understand the underlying mechanisms—the so-called reductionist approach. Mathematical models were developed to test theories of sleep regulation and guide new experiments at each of these levels and have become an integral part of the field. The advantage of modelling, however, is that it allows us to simulate and test the dynamics of complex biological systems and thus provides a tool to investigate the connections between the different levels and study the system as a whole. In this paper I review key models of sleep developed at different physiological levels and discuss the potential for an integrated systems biology approach for sleep regulation across these levels. I also highlight the necessity of building mechanistic connections between models of sleep and circadian rhythms across these levels. View Full-Text
Keywords: sleep; circadian clocks; mathematical modelling; behaviour; mean field; neurons; molecular mechanisms; EEG; systems biology; multi-scale sleep; circadian clocks; mathematical modelling; behaviour; mean field; neurons; molecular mechanisms; EEG; systems biology; multi-scale
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Postnova, S. Sleep Modelling across Physiological Levels. Clocks & Sleep 2019, 1, 166-184.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Clocks & Sleep EISSN 2624-5175 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top