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Open AccessCase Report

Metastatic Cutaneous Squamous Cell Cancer with Peritoneal Carcinomatosis: A Case Report

1
First Oncological Clinic, HYGEIA Hospital, Erythrou Stavrou 4 and Kifisias Avenue, Marousi, 15123 Athens, Greece
2
Second Oncological Clinic, Agios Savvas Hospital, Alexandras Avenue 171, 11522 Athens, Greece
*
Author to whom correspondence should be addressed.
Received: 19 January 2019 / Revised: 23 February 2019 / Accepted: 28 February 2019 / Published: 1 March 2019
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PDF [173 KB, uploaded 1 March 2019]
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Abstract

Peritoneal involvement as a metastatic site of squamous cell skin cancer is exceptionally rare. The current work analyzes a 52-year old male with high-risk cutaneous squamous cell nose carcinoma (cSCC) that was initially treated with surgery and platinum-based concurrent chemoradiation. Five years later, he presented jaundice and hypercalcemia. Further imaging revealed diffused liver, peritoneal and paraaortic lymph node metastases without evidence of locoregional recurrence. The patient underwent liver biopsy, which confirmed the diagnosis. High-risk features for metastasizing can be considered the maximum clinical diameter, the anatomical subsite (localization of the primary tumor in the ear and retroauricular area, cheek and lip are considered to significantly increase the risk of distant metastasis), poor histological differentiation, perineural invasion and lesions with a thickness of more than 2.0 mm. Late relapse that involves only disseminated abdominal disease is very uncommon and may justify closer follow-up and more aggressive chemotherapy in high-risk patients. View Full-Text
Keywords: cutaneous squamous cell cancer; peritoneal carcinomatosis; metastasis; malignancy of skin cutaneous squamous cell cancer; peritoneal carcinomatosis; metastasis; malignancy of skin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mitsimponas, N.; Grivas, A. Metastatic Cutaneous Squamous Cell Cancer with Peritoneal Carcinomatosis: A Case Report. Reports 2019, 2, 8.

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