The Impact of Neuroglia on Vestibular Disorders: Insights and Implications

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

In the article entitled “The Impact of Neuroglia of Vestibular Disorders: Insights and Implications”, the authors review neuroglia in vestibular disorders.

Implications,” the authors review neuroglia in vestibular disorders.

The article addresses an interesting field on glia and vestibular disorders.

There are several points to be addressed.

1.             It is important to include primary sources and not just rely on reviews. That is, to add experimental data.

2. Therapeutic implications are mentioned, so it would be important to present concrete proposals that can be applied in the clinic.

3.             Most of the conclusions are based on animal models and in vitro models, which could reduce the relevance in the clinical field.

4.             Strengthen the clinical approach, to guide the development of therapies.

5.             To enrich the discussion in relation to glia and systemic factors, such as metabolic comorbidities.

6.             Inserting a schematic would be important.

Author Response

Thank you for your valuable comments on our manuscript, "The Impact of Neuroglia on Vestibular Disorders: Insights and Implications." We have carefully addressed all the suggested points and incorporated the necessary revisions into the manuscript.

1. We have thoroughly reviewed the literature again and included additional primary sources where relevant. However, given the limited experimental data available on this topic, our discussion remains largely based on the most up-to-date findings.

2. Regarding therapeutic implications, we have expanded the discussion to include more concrete proposals that could be applied in clinical practice, based on the current evidence available.

3. While we acknowledge that many conclusions are derived from animal and in vitro models, this reflects the current state of research in this field. We have explicitly discussed these limitations and emphasized the need for further clinical studies.

4. We have strengthened the clinical approach by integrating more translational perspectives and highlighting potential clinical applications of neuroglial research in vestibular disorders.

5. The discussion on neuroglia and systemic factors has been enriched, particularly concerning metabolic comorbidities and their potential impact on vestibular dysfunction.

6. A schematic has been included as requested to enhance the visualization of key concepts.

We appreciate the opportunity to refine our work and trust that these revisions have improved the manuscript. However, despite an extensive re-evaluation of the current literature, some of the requested points remain insufficiently explored in published research, as this remains a developing field with limited data available.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

This is a review paper about the roles of neuroglia in vestibular disorders. This is a potentially interesting and useful paper for the readers worldwide. I have a few comments about it.  

#I understand that Table 1 corresponds to Chapter 3 and Table 2 corresponds to Chapter 5. Then, why NOT the table corresponding to Chapter 4? Just a text filled with just words is boring and difficult to follow. I recommend the table corresponding to Chapter 4 be inserted into the MS.

#I understand that this review focuses on glial cells in vestibular disorders. But according to the authors, the roles of neurons in vestibular disorders have already been extensively explored. The interaction between glial cells and neurons must be actively operative in the pathophysiology of vestibular disorders. To know something important (key points) about neurons in vestibular disorders may be necessary to understand glial cells more deeply in these disorders. Personally, I am interested in the role of neuronal-glial interaction in the pathophysiology in vestibular disorders. Just a bit of chapter or subsection dealing with these points,  accompanied by a nice and understandable table, may enhance the value of this review paper.

#The MS is well-written with a good command of English, but some minor typos/grammatical errors noted in the Ms. Please proofread the MS again.

Ex.

-The very last of Abstract: for these disorders > for these disorders.

-Introduction: Each of these conditions’ > Each of these conditions

-Etc.

Author Response

Thank you for your detailed feedback on our manuscript, "The Impact of Neuroglia on Vestibular Disorders: Insights and Implications." We appreciate your valuable suggestions and have carefully reviewed and addressed each of your comments.

1. We have thoroughly revised the manuscript and re-evaluated the available literature. However, it was challenging to find additional primary sources, as the current body of research on neuroglia in vestibular disorders remains limited.

2. Regarding the tables, we acknowledge the gap in Chapter 4 and have now incorporated an additional table to improve clarity and readability.

3. We agree that the interaction between glial cells and neurons is crucial in the pathophysiology of vestibular disorders. We have now included a subsection discussing key aspects of neuron-glia interactions, along with a new table summarizing these interactions to enhance the manuscript’s value.

4. We have conducted a careful proofreading of the manuscript and corrected minor typographical and grammatical errors.

5. We have added an schematic about the therapeutica approaches of glia. Thanks so much for this suggestion

Round 2

Reviewer 1 Report

Comments and Suggestions for Authors

I thank the authors for the changes done to the manuscript. However, I do not see the added schematic.
Would you be so kind as to add it. Thank you very much

Author Response

Thanks so much for your comments

We have added an schematic figure about the therapeutic approaches of glia

Thanks for all your suggestions