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Volume 85
Issue 3
10.5603/ARM.2017.0029
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Review

Signaling Pathways and Their Mirna Regulators Involved in the Etiopathology of Idiopathic Pulmonary Fibrosis (IPF) and Hypersensitivity Pneumonitis (HP)

by
Justyna Kiszałkiewicz
1,
Wojciech J. Piotrowski
2 and
Ewa Brzeziańska-Lasota
1,*
1
Department of Molecular Bases of Medicine, 1st Chair of Internal Medicine, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland
2
Department of Pneumology and Allergy, 1st Chair of Internal Medicine, Medical University of Lodz, Lodz, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2017, 85(3), 169-178; https://doi.org/10.5603/ARM.2017.0029
Submission received: 17 November 2016 / Revised: 2 June 2017 / Accepted: 2 June 2017 / Published: 13 June 2017

Abstract

Idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP) belong to heterogenic group of interstitial lung diseases (ILD). For the reason that this group of diseases present with complex clinical non-specific features, they represent a diagnostic and therapeutic challenge. In this review we focus on several crucial signaling pathways participating in inflammation, fibrosis and EMT processes, so important in the course of ILD: TNF-α/NFκβ, TGF-β/SMAD, Wnt-β-catenin and PI3K-Akt signaling. Moreover, this review summarizes the role of selected signaling pathways and some miRNAs which are their regulators during development and progression of IPF and HP. Recent advances indicate the potential role of miRNAs as a molecular markers differentiating clinical course of ILD.
Keywords: idiopathic pulmonary fibrosis; hypersensitivity pneumonitis; molecular markers; pathogenesis; signaling pathways idiopathic pulmonary fibrosis; hypersensitivity pneumonitis; molecular markers; pathogenesis; signaling pathways

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MDPI and ACS Style

Kiszałkiewicz, J.; Piotrowski, W.J.; Brzeziańska-Lasota, E. Signaling Pathways and Their Mirna Regulators Involved in the Etiopathology of Idiopathic Pulmonary Fibrosis (IPF) and Hypersensitivity Pneumonitis (HP). Adv. Respir. Med. 2017, 85, 169-178. https://doi.org/10.5603/ARM.2017.0029

AMA Style

Kiszałkiewicz J, Piotrowski WJ, Brzeziańska-Lasota E. Signaling Pathways and Their Mirna Regulators Involved in the Etiopathology of Idiopathic Pulmonary Fibrosis (IPF) and Hypersensitivity Pneumonitis (HP). Advances in Respiratory Medicine. 2017; 85(3):169-178. https://doi.org/10.5603/ARM.2017.0029

Chicago/Turabian Style

Kiszałkiewicz, Justyna, Wojciech J. Piotrowski, and Ewa Brzeziańska-Lasota. 2017. "Signaling Pathways and Their Mirna Regulators Involved in the Etiopathology of Idiopathic Pulmonary Fibrosis (IPF) and Hypersensitivity Pneumonitis (HP)" Advances in Respiratory Medicine 85, no. 3: 169-178. https://doi.org/10.5603/ARM.2017.0029

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