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Volume 83
Issue 2
10.5603/PiAP.2015.0024
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Case Report

Pulmonary Artery Stenosis Due to Embryonal Carcinoma with Primary Mediastinal Location

by
Franciszek Grzegorczyk
1,*,
Małgorzata Dybowska
1,
Paweł Kuca
1,
Cezary Czajka
1,
Janusz Burakowski
1,
Renata Langfort
2,
Tadeusz Orłowski
3 and
Witold Tomkowski
1
1
Cardiopulmonary Intensive Care Unit, National Tuberculosis and Lung Diseases Research Institute, 01-138 Warsaw, Poland
2
Department of Pathology, National Tuberculosis and Lung Diseases Research Institute, 01-138 Warsaw, Poland
3
Department of Thoracic Surgery, National Tuberculosis and Lung Diseases Research Institute, 01-138 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2015, 83(2), 151-156; https://doi.org/10.5603/PiAP.2015.0024
Submission received: 8 August 2014 / Revised: 10 March 2015 / Accepted: 10 March 2015 / Published: 10 March 2015

Abstract

A 29-year old man was admitted to the intensive care unit after losing consciousness. On physical examination, a loud systolic murmur over the heart was found. Echocardiography revealed narrowing of pulmonary artery with high pressure gradient. Computed tomography of the chest revealed the presence of large tumour localised in the upper anterior mediastinum. Due to the risk of total closure of the pulmonary artery, interventional mediastinotomy was performed and diagnosis of carcinoma embryonale was established. Subsequent chemotherapy (BEP regimen) has brought regression of tumour and significant improvement in haemodynamic parameters (relief of pressure gradient in pulmonary artery). During the second surgery, the resection of all accessible tumour mass together with marginal resection of the right upper lobe was performed. No signs of cardiac or great vessels infiltration was found. Histopathologic examination revealed the necrotic masses and neoplastic foci diagnosed as teratoma immaturum. In a four-month follow-up the patient’s condition remained good. The patient is still under the care of both oncological and cardiological specialists. Thus far he has not required further chemotherapy. Holter ECG monitoring revealed no arrhythmia, but the patient is still treated with mexiletine. The patient is planning to return to work.
Keywords: pulmonary artery stenosis; embryonal carcinoma; mixed germ cell tumour; primary mediastinal location; mexiletine pulmonary artery stenosis; embryonal carcinoma; mixed germ cell tumour; primary mediastinal location; mexiletine

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MDPI and ACS Style

Grzegorczyk, F.; Dybowska, M.; Kuca, P.; Czajka, C.; Burakowski, J.; Langfort, R.; Orłowski, T.; Tomkowski, W. Pulmonary Artery Stenosis Due to Embryonal Carcinoma with Primary Mediastinal Location. Adv. Respir. Med. 2015, 83, 151-156. https://doi.org/10.5603/PiAP.2015.0024

AMA Style

Grzegorczyk F, Dybowska M, Kuca P, Czajka C, Burakowski J, Langfort R, Orłowski T, Tomkowski W. Pulmonary Artery Stenosis Due to Embryonal Carcinoma with Primary Mediastinal Location. Advances in Respiratory Medicine. 2015; 83(2):151-156. https://doi.org/10.5603/PiAP.2015.0024

Chicago/Turabian Style

Grzegorczyk, Franciszek, Małgorzata Dybowska, Paweł Kuca, Cezary Czajka, Janusz Burakowski, Renata Langfort, Tadeusz Orłowski, and Witold Tomkowski. 2015. "Pulmonary Artery Stenosis Due to Embryonal Carcinoma with Primary Mediastinal Location" Advances in Respiratory Medicine 83, no. 2: 151-156. https://doi.org/10.5603/PiAP.2015.0024

APA Style

Grzegorczyk, F., Dybowska, M., Kuca, P., Czajka, C., Burakowski, J., Langfort, R., Orłowski, T., & Tomkowski, W. (2015). Pulmonary Artery Stenosis Due to Embryonal Carcinoma with Primary Mediastinal Location. Advances in Respiratory Medicine, 83(2), 151-156. https://doi.org/10.5603/PiAP.2015.0024

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