Next Article in Journal
Styles of Coping with Stress and Emotional Functioning in Patients with Asthma
Previous Article in Journal
Treatment Outcomes in Culture-Positive Pulmonary Tuberculosis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
ARM
Volume 77
Issue 1
10.5603/ARM.27849
arm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Abnormalities in High-Resolution Computed Tomography of the Lungs in Patients with Idiopathic Pulmonary Arterial Hypertension—Correlation with Haemodynamic Parameters and Prognostic Significance

by
Aneta Kacprzak
1,
Monika Szturmowicz
1,*,
Barbara Burakowska
2,
Anna Fijałkowska
1,
Marcin Kurzyna
1,
Maria Wieteska
1,
Michał Florczyk
1,
Joanna Żyłkowska
1,
Monika Franczuk
3,
Stefan Wesołowski
3 and
Adam Torbicki
1
1
Department of Chest Medicine, Institute of Tuberculosis and Lung Diseases, 01-138 Warsaw, Poland
2
Radiology Department, Institute of Tuberculosis and Lung Diseases, 01-138 Warsaw, Poland
3
Pathophysiology Department, Institute of Tuberculosis and Lung Diseases, 01-138 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2009, 77(1), 23-30; https://doi.org/10.5603/ARM.27849
Submission received: 29 April 2008 / Revised: 19 December 2008 / Accepted: 19 December 2008 / Published: 19 December 2008

Abstract

Introduction: The risk stratification in idiopathic pulmonary arterial hypertension (IPAH) patients is currently based on haemodynamic and functional parameters as well as serum biomarker concentrations. Until now the importance of changes appearing in high-resolution computed tomography (HRCT) of the lungs of patients with IPAH has not been investigated. Material and methods: Lung HRCT scans were analysed retrospectively in 48 IPAH patients (patients): 37 women, 11 men, mean age 41 ± 15 years. Results: Focal ground-glass opacifications (FGG) were found in 12 patients (25%), and centrilobular nodules (CN) were found in 8 patients (17%). In the remaining 58% of patients HRCT revealed no changes (N). Significantly lower stroke volume was found in the CN group (41.0 ± 8.5 ml) compared to 60.8 ± 15.1 ml in the FGG group and 58.1 ± 18.0 ml in the N group (p = 0.03). Right atrial pressure was significantly higher in the CN group (12.2 ± 4.86 mm Hg) than in the FGG group (6.9 ± 3.9 mm Hg) and the N group (7.6 ± 5.3 mm Hg), p = 0.047. The presence of nodules was combined with considerably increased risk of death, both in univariate analysis (HR 5.35, 95% CI: 1.16–24.7, p = 0.03) and in multivariate analysis (HR 6.98, 95% CI: 1.41–34.59, p = 0.02). Ground-glass opacifications correlated neither with haemodynamic nor functional indexes, and were of no prognostic significance. Conclusions: The presence of centrilobular nodules in lung HRCT scans of IPAH patients was combined with more severe haemodynamic compromise and was an independent negative prognostic indicator.
Keywords: idiopathic pulmonary arterial hypertension; high resolution computed tomography; prognosis idiopathic pulmonary arterial hypertension; high resolution computed tomography; prognosis

Share and Cite

MDPI and ACS Style

Kacprzak, A.; Szturmowicz, M.; Burakowska, B.; Fijałkowska, A.; Kurzyna, M.; Wieteska, M.; Florczyk, M.; Żyłkowska, J.; Franczuk, M.; Wesołowski, S.; et al. Abnormalities in High-Resolution Computed Tomography of the Lungs in Patients with Idiopathic Pulmonary Arterial Hypertension—Correlation with Haemodynamic Parameters and Prognostic Significance. Adv. Respir. Med. 2009, 77, 23-30. https://doi.org/10.5603/ARM.27849

AMA Style

Kacprzak A, Szturmowicz M, Burakowska B, Fijałkowska A, Kurzyna M, Wieteska M, Florczyk M, Żyłkowska J, Franczuk M, Wesołowski S, et al. Abnormalities in High-Resolution Computed Tomography of the Lungs in Patients with Idiopathic Pulmonary Arterial Hypertension—Correlation with Haemodynamic Parameters and Prognostic Significance. Advances in Respiratory Medicine. 2009; 77(1):23-30. https://doi.org/10.5603/ARM.27849

Chicago/Turabian Style

Kacprzak, Aneta, Monika Szturmowicz, Barbara Burakowska, Anna Fijałkowska, Marcin Kurzyna, Maria Wieteska, Michał Florczyk, Joanna Żyłkowska, Monika Franczuk, Stefan Wesołowski, and et al. 2009. "Abnormalities in High-Resolution Computed Tomography of the Lungs in Patients with Idiopathic Pulmonary Arterial Hypertension—Correlation with Haemodynamic Parameters and Prognostic Significance" Advances in Respiratory Medicine 77, no. 1: 23-30. https://doi.org/10.5603/ARM.27849

APA Style

Kacprzak, A., Szturmowicz, M., Burakowska, B., Fijałkowska, A., Kurzyna, M., Wieteska, M., Florczyk, M., Żyłkowska, J., Franczuk, M., Wesołowski, S., & Torbicki, A. (2009). Abnormalities in High-Resolution Computed Tomography of the Lungs in Patients with Idiopathic Pulmonary Arterial Hypertension—Correlation with Haemodynamic Parameters and Prognostic Significance. Advances in Respiratory Medicine, 77(1), 23-30. https://doi.org/10.5603/ARM.27849

Article Metrics

Back to TopTop