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J. Otorhinolaryngol. Hear. Balance Med. 2018, 1(1), 7; https://doi.org/10.3390/ohbm1010007

Role of Autophagy in Auditory System Development and Survival

1,†
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2,3,†
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2,4,†
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1
,
2,3
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2,3
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1
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1,* and 2,3,*
1
Institute of Otorhinolaryngology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
2
Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, China
3
Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China
4
Department of Biotechnology, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi 74700, Pakistan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 4 February 2018 / Revised: 6 April 2018 / Accepted: 14 April 2018 / Published: 16 April 2018
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Abstract

Autophagy is a natural catabolic process of the cell that dismantles the useless or dysfunctional components. Autophagy allows the systematic and the lysosomal-mediated deterioration of cellular organelles. During the embryonic development, autophagy plays a critical role by remodeling the tissue and organs of the body, and the deletion of some of the autophagy related genes results in the defective embryonic development. Inner ear is the most sophisticated organ of the body responsible for the sound perception. In mammalian inner ear, autophagy protects the hair cells (HCs) from drug and noise induced damage. In this review, we particularly discuss how autophagy implicates during the auditory system development in mammals and presents its role in age-related hearing loss. Moreover, we discuss the protecting effects of autophagy after noise and drug induced auditory trauma. View Full-Text
Keywords: autophagy; autophagosome; auditory system development; age-related hearing loss; noise and drug induced hearing loss autophagy; autophagosome; auditory system development; age-related hearing loss; noise and drug induced hearing loss
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He, Z.; Fang, Q.; Waqas, M.; Wu, X.; Cheng, C.; He, L.; Sun, Y.; Kong, W.; Chai, R. Role of Autophagy in Auditory System Development and Survival. J. Otorhinolaryngol. Hear. Balance Med. 2018, 1, 7.

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J. Otorhinolaryngol. Hear. Balance Med. EISSN 2504-463X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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