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Open AccessProceedings

Exploring Inflammatory Status in Febrile Seizures Associated with Urinary Tract Infections: A Two-Step Cluster Approach

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Pediatric Research and Telemedicine Center in Neurological Diseases, Pediatric Clinical Hospital, 550166 Sibiu, Romania
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Mathematics and Informatics Department, Research Center in Informatics and Information Technology, Faculty of Sciences, Lucian Blaga University, 550012 Sibiu, Romania
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Pediatric Neurology Department, Pediatric Clinical Hospital, 550166 Sibiu, Romania
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Medical Department, Faculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania
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Clinical Department, Faculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania
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Computer and Electrical Engineering Department, Faculty of Engineering, Lucian Blaga University, 550025 Sibiu, Romania
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Author to whom correspondence should be addressed.
Presented at the 1st International Electronic Conference on Brain Sciences, 10–25 November 2020; Available online: https://sciforum.net/conference/IECBS.
Proceedings 2021, 71(1), 3; https://doi.org/10.3390/IECBS-08108
Published: 9 February 2021
Background: Urinary tract infections (UTIs) are considered common facilitating factors along with other infections in triggering febrile seizures (FS). The main purpose of our study was to identify specific patterns of UTIs, using a combination of inflammatory biomarkers, in order to differentiate UTIs from other bacterial diseases triggering FS. Method: This study included a number of 197 distinct FS events from patients hospitalized in the Pediatric Clinical Hospital Sibiu, among which 10.2% were diagnosed with UTIs. Results: In one-third of the patients with UTI, the symptoms were limited to fever and FS. Using Two-Step cluster analysis, a distinct inflammatory pattern has emerged: higher platelet distribution of the population (PDW), platelet large cell ratio (P-LCR), mean platelet volume (MPV), C-Reactive Protein (CRP), and neutrophil to lymphocyte ratio (NLR). This pattern was associated mainly with bacterial lower respiratory infections. UTIs were highly unlikely in the patients with significantly increased CRP values and normal values of platelet indices. Conclusion. Considering the nonspecific clinical picture of UTIs at an early age, to optimize the management of FS, a fast diagnosis of UTI is mandatory. Our study suggests that analyzing the inflammatory biomarkers interlinks (rather than individual parameters) could help identify even oligosymptomatic UTIs patients.
Keywords: febrile seizures; urinary tract infections; inflammatory biomarkers; cluster analysis; laboratory data; C-reactive protein; cut-off values febrile seizures; urinary tract infections; inflammatory biomarkers; cluster analysis; laboratory data; C-reactive protein; cut-off values
MDPI and ACS Style

Maniu, I.; Costea, R.M.; Dobrota, L.; Bacila, C.; Neamtu, B.M. Exploring Inflammatory Status in Febrile Seizures Associated with Urinary Tract Infections: A Two-Step Cluster Approach. Proceedings 2021, 71, 3. https://doi.org/10.3390/IECBS-08108

AMA Style

Maniu I, Costea RM, Dobrota L, Bacila C, Neamtu BM. Exploring Inflammatory Status in Febrile Seizures Associated with Urinary Tract Infections: A Two-Step Cluster Approach. Proceedings. 2021; 71(1):3. https://doi.org/10.3390/IECBS-08108

Chicago/Turabian Style

Maniu, Ionela; Costea, Raluca Maria; Dobrota, Luminita; Bacila, Ciprian; Neamtu, Bogdan Mihai. 2021. "Exploring Inflammatory Status in Febrile Seizures Associated with Urinary Tract Infections: A Two-Step Cluster Approach" Proceedings 71, no. 1: 3. https://doi.org/10.3390/IECBS-08108

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