Inflammation and Chronic Diseases: The Polar Lipid Link †
Abstract
:1. Introduction
2. Inflammation, Atherosclerosis, and Cardiovascular Diseases
3. The Potential Use of Platelet-Activating Factor Inhibitors as Therapeutics and Preventatives of Disease
4. PAF Inhibitors and Anti-Inflammatory Foods
5. Conclusions
Author Contributions
Conflicts of Interest
References
- Tsoupras, A.; Lordan, R.; Zabetakis, I. Inflammation, not cholesterol, is a cause of chronic disease. Nutrients 2018, 10, 604. [Google Scholar] [CrossRef] [PubMed]
- Billingsley, H.E.; Carbone, S.; Lavie, C.J. Dietary fats and chronic noncommunicable diseases. Nutrients 2018, 10, 1385. [Google Scholar] [CrossRef] [PubMed]
- Yu, E.; Malik, V.S.; Hu, F.B. Cardiovascular disease prevention by diet modification: JACC health promotion series. J. Am. Coll. Cardiol. 2018, 72, 914–926. [Google Scholar] [CrossRef] [PubMed]
- Lordan, R.; Tsoupras, A.; Zabetakis, I. The potential role of dietary platelet-activating factor inhibitors in cancer prevention and treatment. Adv. Nutr. 2019, 10, 148–164. [Google Scholar] [CrossRef] [PubMed]
- Lordan, R.; Tsoupras, A.; Zabetakis, I.; Demopoulos, A.C. Forty years since the structural elucidation of platelet-activating factor (PAF): Historical, current, and future research perspectives. Molecules 2019, 24, 4414. [Google Scholar] [CrossRef] [PubMed]
- Libby, P. Inflammation in atherosclerosis. Nature 2002, 420, 868–874. [Google Scholar] [CrossRef] [PubMed]
- Lordan, R.; Zabetakis, I. Invited review: The anti-inflammatory properties of dairy lipids. J. Dairy Sci. 2017, 100, 4197–4212. [Google Scholar] [CrossRef] [PubMed]
- Lordan, R.; Tsoupras, A.; Zabetakis, I. Platelet activation and prothrombotic mediators at the nexus of inflammation and atherosclerosis: Potential role of antiplatelet agents. Blood Rev. 2020, 100694. [Google Scholar] [CrossRef] [PubMed]
- Bäck, M.; Yurdagul, A.; Tabas, I.; Öörni, K.; Kovanen, P.T. Inflammation and its resolution in atherosclerosis: Mediators and therapeutic opportunities. Nat. Rev. Cardiol. 2019, 16, 389–406. [Google Scholar] [CrossRef] [PubMed]
- Calder, P.C. The use of n-3 polyunsaturated fatty acids as therapeutic agents for inflammatory diseases. Immunol. Endocr. Metab. Agents 2009, 9, 45–54. [Google Scholar] [CrossRef]
- Calder, P.C. Omega-3 polyunsaturated fatty acids and inflammatory processes: Nutrition or pharmacology? Br. J. Clin. Pharmacol. 2013, 75, 645–662. [Google Scholar] [CrossRef] [PubMed]
- Montrucchio, G.; Alloatti, G.; Camussi, G. Role of platelet-activating factor in cardiovascular pathophysiology. Physiol. Rev. 2000, 80, 1669–1699. [Google Scholar] [CrossRef] [PubMed]
- Sioriki, E.; Lordan, R.; Nahra, F.; van hecke, K.; Zabetakis, I.; Nolan, S.P. In vitro anti-atherogenic properties of n-heterocyclic carbene aurate(I) compounds. ChemMedChem 2018, 13, 2484–2487. [Google Scholar] [CrossRef] [PubMed]
- Lordan, R.; Nasopoulou, C.; Tsoupras, A.; Zabetakis, I. The anti-inflammatory properties of food polar lipids. In Bioactive Molecules in Food; Mérillon, J.M., Ramawat, K.G., Eds.; Springer International Publishing: Cham, Switzerland, 2018; pp. 1–34. [Google Scholar]
- Masana, L.; Ros, E.; Sudano, I.; Angoulvant, D. Is there a role for lifestyle changes in cardiovascular prevention? What, when and how? Atheroscler. Supp. 2017, 26, 2–15. [Google Scholar] [CrossRef]
- O’Keefe, J.H.; Gheewala, N.M.; O’Keefe, J.O. Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J. Am. Coll. Cardiol. 2008, 51, 249–255. [Google Scholar] [CrossRef] [PubMed]
- Martínez-González, M.A.; Gea, A.; Ruiz-Canela, M. The mediterranean diet and cardiovascular health. Circ. Res. 2019, 124, 779–798. [Google Scholar] [CrossRef] [PubMed]
- Soltani, S.; Chitsazi, M.J.; Salehi-Abargouei, A. The effect of dietary approaches to stop hypertension (DASH) on serum inflammatory markers: A systematic review and meta-analysis of randomized trials. Clin. Nutr. 2018, 37, 542–550. [Google Scholar] [CrossRef] [PubMed]
- Tierney, A.; Lordan, R.; Tsoupras, A.; Zabetakis, I. Chapter 8—Diet and cardiovascular disease: The mediterranean diet. In The Impact of Nutrition and Statins on Cardiovascular Diseases; Zabetakis, I., Lordan, R., Tsoupras, A., Eds.; Elsevier: Cambridge, MA, USA, 2019; pp. 267–288. [Google Scholar]
- Dehghan, M.; Mente, A.; Zhang, X.; Swaminathan, S.; Li, W.; Mohan, V.; Iqbal, R.; Kumar, R.; Wentzel-Viljoen, E.; Rosengren, A.; et al. Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): A prospective cohort study. Lancet 2017, 390, 2050–2062. [Google Scholar] [CrossRef]
- Lordan, R.; Redfern, S.; Tsoupras, A.; Zabetakis, I. Inflammation and cardiovascular disease: Are marine phospholipids the answer? Food Funct. 2020, 11, 2861–2885. [Google Scholar] [CrossRef] [PubMed]
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Lordan, R.; Zabetakis, I.; Tsoupras, A. Inflammation and Chronic Diseases: The Polar Lipid Link. Proceedings 2021, 70, 70. https://doi.org/10.3390/foods_2020-07598
Lordan R, Zabetakis I, Tsoupras A. Inflammation and Chronic Diseases: The Polar Lipid Link. Proceedings. 2021; 70(1):70. https://doi.org/10.3390/foods_2020-07598
Chicago/Turabian StyleLordan, Ronan, Ioannis Zabetakis, and Alexandros Tsoupras. 2021. "Inflammation and Chronic Diseases: The Polar Lipid Link" Proceedings 70, no. 1: 70. https://doi.org/10.3390/foods_2020-07598