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Open AccessProceedings

Determination of Intrinsic and Metrological Correlations of Components of Product Impact on Risks of False Decisions in Conformity Assessment

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Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, 05508-000 São Paulo, Brazil
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Centro de Química Estrutural, Faculdade de Ciências da Universidade de Lisboa, 1749-016 Lisbon, Portugal
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Author to whom correspondence should be addressed.
Presented at the Virtual Eurachem Workshop 2020—“Quality Assurance for Analytical Laboratories in the University Curriculum”, 14–15 July 2020; Available online: https;//eurachem2020.ro/.
Proceedings 2020, 55(1), 5; https://doi.org/10.3390/proceedings2020055005
Published: 18 September 2020
The correlation between the measured values of product components can influence the total risk of false decisions in conformity assessment. This correlation can originate from the characteristics of the product (intrinsic) or from how the components are measured (metrological). This work aimed to determine both correlations by testing a medicine with two compounds separately and together (correlated). The same intrinsic correlation was estimated regardless of whether the measurements were independent or correlated. Furthermore, the intrinsic covariance contributed significantly to the total covariance between the components evaluated. Both metrological and intrinsic correlations should be considered, as they can affect the risks of false decisions in conformity assessment when there are two or more compounds associated in the product.
Keywords: covariance; correlation; drug association; conformity assessment covariance; correlation; drug association; conformity assessment
MDPI and ACS Style

Separovic, L.; Silva, R.J.N.B.; Lourenço, F.R. Determination of Intrinsic and Metrological Correlations of Components of Product Impact on Risks of False Decisions in Conformity Assessment. Proceedings 2020, 55, 5.

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