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Open AccessAbstract

Anticancer Activity of Lichen Extract (Usnea sp.) Based Synthesized [email protected] Bimetallic Nanocomposite

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Department of Biology, Faculty of Science, Erciyes University, Kayseri 38039, Turkey
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Department of Pharmacology, Faculty of Pharmacy, Erciyes University, Kayseri 38039, Turkey
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Department of Aquatic Animal and Diseases, Faculty of Veterinary Medicine, Erciyes University, Kayseri 38039, Turkey
*
Author to whom correspondence should be addressed.
Presented at the 3rd International conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 18–20 December 2019.
Proceedings 2019, 40(1), 51; https://doi.org/10.3390/proceedings2019040051
Published: 3 March 2020
Bimetallic nanoparticles (NP) have improved properties such as antimicrobial, anticancer and photocatalytic activity due to the synergistic effects of their components. Unmet needs of the current cancer treatments encourage researchers for the new treatment approaches especially natural products. In this study, we aimed to investigate the antiproliferative effects of [email protected] NP on the SH-SY5Y human neuroblastoma cell line. [email protected] NP was dispersed in distilled water via ultrasonication and diluted with the medium as the 5, 10, 25, 50, 100, 200 and 400 μg/mL final concentrations. The cell viabilities were investigated by MTT test at 24th hours of [email protected] NP treatments. In MTT test, the lower concentrations of [email protected] NP (5, 10, 25 μg/mL) increased the cell viability (p < 0.01, p < 0.01 and p < 0.05, respectively) whereas it was markedly decreased (p < 0.001) the cell viabilities at higher concentrations (100, 200 and 400 ug/ml) compared with the control group. Our results showed that [email protected] NP has antiproliferative effects on SH-SY5Y cells whereas it increases cell proliferation in the low dose. The effects in the low dose may depend on its activation of compensatory mechanisms in the cell. We have thought that it is worthwhile to research its anticancer potential on the different cancer cell lines.
Keywords: silver and zinc oxide nanoparticles; SH-SY5Y; cytotoxicity; cancer silver and zinc oxide nanoparticles; SH-SY5Y; cytotoxicity; cancer
MDPI and ACS Style

Isik, Y.; Unal, G.; Koca, F.D.; Halici, M.G. Anticancer Activity of Lichen Extract (Usnea sp.) Based Synthesized [email protected] Bimetallic Nanocomposite. Proceedings 2019, 40, 51.

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