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Abstract

The Anti-Tumoral Effects of Wolfberry (Lycium barbarum) on Experimentally Induced Ehrlich Ascites Carcinoma in Mice †

1
Department of Anatomy, Faculty of Medicine, Erciyes University, 38030 Kayseri, Turkey
2
Department of Pharmacognosy, Faculty of Pharmacy, Erciyes University, 38030 Kayseri, Turkey
*
Author to whom correspondence should be addressed.
Presented at the 3rd International conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 18–20 December 2019.
Proceedings 2019, 40(1), 38; https://doi.org/10.3390/proceedings2019040038
Published: 30 December 2019

Abstract

:
Wolfberry (Lycium barbarum) shows strengthen immune system, antioxidant and anticancerogenic effect. In this research, the effects of Wolfberry's extract fractions, cultivated in Kayseri, investigated on Ehrlich ascites tumor (EAT) using in vivo and in vitro techniques. For in vivo study, 200 mg/kg fractions of Wolfberry extract (above and below 50 kDa) were injected ip to EAT injected Balb/C mice. EAT cells were also cultured in the presence of Wolfberry's extract fractions (1500, 2000 µg/ml) to examine cell vitality and apoptosis using the Muse Cell Analyzer. Histopathological examination of intra-abdominal organs showed that there were decrease in the EAT cells adherence in the Wolfberry applied tissue groups when compared to the control. According to in vitro results, the both extract fractions (above and below 50 kDa) increased apoptosis in cancer cells. However, total apoptotic cell percentage was higher and statistically significant in groups above 50 kDa (1500, 2000 mg/ml) (p < 0.05). Previous literature and the results of the present study reveal that the consumption of wolfberry—which is also produced in Turkey—might be effective in preventing the formation of cancer and the deceleration of its progress.

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MDPI and ACS Style

Uçar, S.; Ülger, H.; AL, Ö.; Nisari, M.; Karatoprak, G.Ş. The Anti-Tumoral Effects of Wolfberry (Lycium barbarum) on Experimentally Induced Ehrlich Ascites Carcinoma in Mice. Proceedings 2019, 40, 38. https://doi.org/10.3390/proceedings2019040038

AMA Style

Uçar S, Ülger H, AL Ö, Nisari M, Karatoprak GŞ. The Anti-Tumoral Effects of Wolfberry (Lycium barbarum) on Experimentally Induced Ehrlich Ascites Carcinoma in Mice. Proceedings. 2019; 40(1):38. https://doi.org/10.3390/proceedings2019040038

Chicago/Turabian Style

Uçar, Sümeyye, Harun Ülger, Özge AL, Mehtap Nisari, and Gökçe Şeker Karatoprak. 2019. "The Anti-Tumoral Effects of Wolfberry (Lycium barbarum) on Experimentally Induced Ehrlich Ascites Carcinoma in Mice" Proceedings 40, no. 1: 38. https://doi.org/10.3390/proceedings2019040038

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