Next Article in Journal
Rational Design, Synthesis, and Characterization of Glycoconjugates as Potential Vaccines against Tuberculosis
Previous Article in Journal
Recent Advances in Discovery of New Tyrosine Kinase Inhibitors Using Computational Methods
Open AccessAbstract

Novel Dual PDK1/AurK-A Inhibitors for Cancer Therapy: Med Chem Evolution and Crystallographic Investigation

1
Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
2
BioStructures Lab, [email protected]—Istituto Italiano di Tecnologia, 56126 Pisa, Italy
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 45; https://doi.org/10.3390/proceedings2019022045
Published: 8 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
PDF [119 KB, uploaded 8 August 2019]
Note: In lieu of an abstract, this is an excerpt from the first page.

Excerpt

The struggle to find novel efficacious pharmacological approaches for cancer treatment has led
to the identification of several kinases involved in neoplastic genesis and cell development. [...]
Keywords: PDK1/AurK-A inhibitors; kinase inhibitors; drug discovery; medicinal chemistry; crystallography; cancer therapy PDK1/AurK-A inhibitors; kinase inhibitors; drug discovery; medicinal chemistry; crystallography; cancer therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Sestito, S.; Chiarugi, S.; Margheritis, E.; Runfola, M.; Bertini, S.; Garau, G.; Rapposelli, S. Novel Dual PDK1/AurK-A Inhibitors for Cancer Therapy: Med Chem Evolution and Crystallographic Investigation. Proceedings 2019, 22, 45.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Proceedings EISSN 2504-3900 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top