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Design, Synthesis, and Biological Evaluation of Bimodal Glycopeptides as Inhibitors of Neurotoxic Protein Aggregation

1
Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia
2
School of Pharmacy and Pharmacology, Griffith University, Gold Coast 4222, Australia
3
Quality Use of Medicines Network, Griffith University, Gold Coast 4222, Australia
4
Griffith Institute for Drug Discovery, Griffith University, Nathan 4111, Australia
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 32; https://doi.org/10.3390/proceedings2019022032
Published: 7 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
PDF [183 KB, uploaded 7 August 2019]
Note: In lieu of an abstract, this is an excerpt from the first page.

Excerpt

Post-translational modifications (PTM) of proteins are becoming the focus of a growing base of [...]
Keywords: α-Synuclein aggregation; Parkinson’s disease; O-GlcNAcylation; neurodegenerative diseases α-Synuclein aggregation; Parkinson’s disease; O-GlcNAcylation; neurodegenerative diseases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ryan, P.; Xu, M.; Davey, A.K.; Mellick, G.D.; Rudrawar, S. Design, Synthesis, and Biological Evaluation of Bimodal Glycopeptides as Inhibitors of Neurotoxic Protein Aggregation. Proceedings 2019, 22, 32.

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