Lab-on-Chip Prototype for the Detection of Coronary Artery Disease Biomarkers†
AbstractWe report an easy-to-use Lab-on-Chip (LoC) device able to detect soluble, circulating biomarkers in plasma that are relevant to Coronary Artery Disease (CAD). The LoC prototype is developed within the SMARTool European project and is intended to be used for Point-of-Care (PoC) testing of patients with CAD, facilitating more rapid and efficient monitoring and treatment decisions. A LoC prototype is presented, enabling chemiluminescent assays to be performed on chip targeting biomarkers relevant to CAD. In parallel, a robust technology for electrostatically actuated, capillary burst valve for PoC applications, integrated in potentially disposable, thermoplastic devices is reported. The devices were fabricated using easily scalable fabrication techniques and can be used to perform multistep assays on single-use microfluidic devices.
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Tsopela, A.; Meucci, S.; Rocchiccioli, S.; Pelosi, G.; Brivio, M. Lab-on-Chip Prototype for the Detection of Coronary Artery Disease Biomarkers. Proceedings 2018, 2, 390.
Tsopela A, Meucci S, Rocchiccioli S, Pelosi G, Brivio M. Lab-on-Chip Prototype for the Detection of Coronary Artery Disease Biomarkers. Proceedings. 2018; 2(8):390.Chicago/Turabian Style
Tsopela, Aliki; Meucci, Sandro; Rocchiccioli, Silvia; Pelosi, Gualtiero; Brivio, Monica. 2018. "Lab-on-Chip Prototype for the Detection of Coronary Artery Disease Biomarkers." Proceedings 2, no. 8: 390.
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