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Proceedings 2018, 2(8), 390; https://doi.org/10.3390/ICEM18-05215

Lab-on-Chip Prototype for the Detection of Coronary Artery Disease Biomarkers

1
Micronit Microtechnologies BV, 7511 AH Enschede, The Netherlands
2
Institute of Clinical Physiology CNR, 56124 Pisa, Italy
Presented at the 18th International Conference on Experimental Mechanics, Brussels, Belgium, 1–5 July 2018.
*
Author to whom correspondence should be addressed.
Published: 9 May 2018
PDF [1693 KB, uploaded 30 May 2018]

Abstract

We report an easy-to-use Lab-on-Chip (LoC) device able to detect soluble, circulating biomarkers in plasma that are relevant to Coronary Artery Disease (CAD). The LoC prototype is developed within the SMARTool European project and is intended to be used for Point-of-Care (PoC) testing of patients with CAD, facilitating more rapid and efficient monitoring and treatment decisions. A LoC prototype is presented, enabling chemiluminescent assays to be performed on chip targeting biomarkers relevant to CAD. In parallel, a robust technology for electrostatically actuated, capillary burst valve for PoC applications, integrated in potentially disposable, thermoplastic devices is reported. The devices were fabricated using easily scalable fabrication techniques and can be used to perform multistep assays on single-use microfluidic devices.
Keywords: Lab-on-Chip; polymer-based microfluidics; cardiac biomarkers Lab-on-Chip; polymer-based microfluidics; cardiac biomarkers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Tsopela, A.; Meucci, S.; Rocchiccioli, S.; Pelosi, G.; Brivio, M. Lab-on-Chip Prototype for the Detection of Coronary Artery Disease Biomarkers. Proceedings 2018, 2, 390.

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