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Proceedings 2018, 2(25), 1572;

RHO Gene Polymorphisms in Patients with Pterygium

Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey
Department of Physiology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey
Department of Ophthalmology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey
Department of Medical Biochemistry, Faculty of Medicine, Harran University, 63290 Sanliurfa, Turkey
Department of Medical Biology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey
Author to whom correspondence should be addressed.
Presented at the 2nd International Cell Death Research Congress, Izmir, Turkey, 1–4 November 2018.
Published: 6 December 2018
(This article belongs to the Proceedings of Cell Death 2018)
PDF [199 KB, uploaded 21 December 2018]


Pterygium is one of the most common ocular surface diseases, and characterized by inflammatory infiltrates, proliferation, fibrosis, angiogenesis, and extracellular matrix breakdown. We investigated the association of polymorphisms in the RHO genes RHOA, RHOB, RHOC, RHOD, and RND3 (RHOE). The results of this study demonstrate for the first time the association of RHO genes with the pterygium. We displayed that the RHO gene polymorphisms were significantly associated with pterygium in the Turkish population.
Keywords: polymorphism; pterygium; Rho proteins polymorphism; pterygium; Rho proteins
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Saracaloglu, A.; Demiryürek, S.; Kimyon, S.; Mete, A.; Temiz, E.; Nacarkahya, G.; Saygili, O.; Güngör, K.; Demiryürek, A.T. RHO Gene Polymorphisms in Patients with Pterygium. Proceedings 2018, 2, 1572.

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