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Proceedings 2018, 2(25), 1565; https://doi.org/10.3390/proceedings2251565

The Cytotoxic Effects of Humic Acid on Human Breast Cancer Cells

1
Department of Biophysics, Faculty of Medicine, Near East University, Nicosia 99010, Cyprus
2
Department of Biochemistry, Faculty of Pharmacy, Near East University, Nicosia 99010, Cyprus
3
Experimental Health Sciences Research Center, Near East University, Nicosia 99010, Cyprus
4
Vocational School of Health Sciences, Near East University, Nicosia 99010, Cyprus
5
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Near East University, Nicosia 99010, Cyprus
6
Department of Histology and Embryology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey
Presented at the 2nd International Cell Death Research Congress, Izmir, Turkey, 1–4 November 2018.
*
Author to whom correspondence should be addressed.
Published: 7 December 2018
PDF [424 KB, uploaded 7 December 2018]

Abstract

Breast cancer is the most common cancer among women and in order to create alternative treatments different types of in vivo and in vitro studies have used various plant-based therapeutic agents. Humic acid (HA) induces apoptosis and has various pharmacological properties including anti-inflammatory and anti-proliferative effects. In our study, we examined the cytotoxic effects of HA at concentrations of 5, 10, 20, 50 and 100 μg/mL in human breast adenocarcinoma MCF-7 cell line for 24 and 48 h. By using MTT method, it has been found out that HA 100 g/mL had cytotoxic effect on human breast adenocarcinoma MCF-7 cell line at both 24 and 48 h; also found out that the effective dose of HA at the same time (24 and 48 h) was 50 μg/mL. The results of our study will shed light on the development of alternative therapeutic approaches in the treatment of cancer by evaluating the cytotoxic effect of HA.
Keywords: humic acid; human breast adenocarcinoma MCF-7 cell line; MTT humic acid; human breast adenocarcinoma MCF-7 cell line; MTT
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Aykac, A.; Becer, E.; Okcanoğlu, T.B.; Güvenir, M.; Süer, K.; Vatansever, S. The Cytotoxic Effects of Humic Acid on Human Breast Cancer Cells. Proceedings 2018, 2, 1565.

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