Development of Non-Antibiotic-Based Formulations and Materials for the Treatment of Recurrent Vaginal Infections ^†

1. Introduction

Vaginal infections remain a prevalent global health concern among women, often resulting in symptoms such as pain, itchiness, and dysuria (1). Despite available treatments, recurrence and persistence of infections are common. This study explores a novel therapeutic approach using bioactive films composed of curcumin and Myrtus communis to manage recurrent vaginal infections. Importantly, the goal is to identify a natural solution that avoids the use of antibiotics, addressing concerns related to antibiotic resistance and the side effects associated with conventional treatments.

2. Methodology

Films were formulated using 2% sodium alginate and 10% polyvinyl alcohol (PVA), embedded separately with either pure curcumin or Myrtus communis extract to assess their individual contributions to the film’s performance. The swelling behavior of each film type was assessed using standardized 1 × 1 cm samples, providing a reliable measure of their capacity to absorb moisture, which is critical for their functionality in a vaginal environment.

3. Preliminary Results

Both types of circular film samples exhibited swelling behavior. Notably, the curcumin-based films demonstrated superior swelling capacity compared to the Myrtus communis films; this difference might enhance the retention of moisture, which is beneficial for maintaining prolonged contact with the mucosal surface.

4. Conclusions and Future Work

The curcumin-based films showed promising swelling characteristics, suggesting potential for improved mucosal adherence and drug delivery in the vaginal environment. Further research is underway to enhance the swelling properties of the Myrtus communis films and evaluate the antimicrobial efficacy of both formulations.