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Abstract

The Use of Plant-Derived Biomaterials as Drug Formulation Excipients: An Application of Biomimetics in Dosage Form Development †

by
Omobolanle Ayoyinka Omoteso
*,
Yusuf Oluwagbenga Ghazali
and
Michael Ayodele Odeniyi
Department of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Ibadan 200005, Nigeria
*
Author to whom correspondence should be addressed.
†
Presented at the 1st International Online Conference on Biomimetics (IOCB 2024), 15–17 May 2024; Available online: https://sciforum.net/event/IOCB2024.
Proceedings 2024, 107(1), 42; https://doi.org/10.3390/proceedings2024107042
Published: 15 May 2024
Versions Notes

1. Introduction

To develop an active drug into a suitable dosage form, pharmaceutical scientists combine various excipients (additives) obtained from different sources. Considering the trends of advancements in the field of biomimetics, we hypothesize that biomaterials contained in different plant parts have inherent biological properties that can mimic what is desired of a drug excipient. In this project, the researchers seek to explore a range of plant-derived constituents and analyze them towards optimizing their use as pharmaceutical excipients in dosage form development.

2. Method

A range of desired pharmaceutical product qualities was selected to be the focus of the study. Following this, a comprehensive literature survey is being carried out to identify plant and herb parts with documented records of possessing these desired traits in their composition and biological activity. The availability of these plant parts in Africa was also considered. The identified plant parts will be collected, after which the constituents of interest will be extracted from them. These constituents will be characterized and optimized for the prospects of enhancing pharmaceutical formulations, leveraging their natural pathways of activity.

3. Results

The following dosage form properties have been identified as the primary considerations in this study: bioadhesion/mucoadhesion, disintegration, solubilization, binding, thickening, and taste enhancement. A literature survey is ongoing to determine what plants elicit these properties in their natural life cycles. The outcome of this literature exploration will guide the plant procurement and extraction phases.

4. Conclusions

Driven by the possibility of having plant constituents replicate their biological characteristics upon incorporation in pharmaceutical dosage forms, this study expects to generate usable biomimetic-derived drug excipients in a bid to make final pharmaceutical products more affordable and therapeutically effective.

Supplementary Materials

The presentation material of this work is available online at https://www.mdpi.com/article/10.3390/proceedings2024107042/s1.

Author Contributions

Conceptualization, O.A.O.; methodology, O.A.O. and Y.O.G.; software, O.A.O. and Y.O.G.; validation, O.A.O. and Y.O.G. and M.A.O.; formal analysis, O.A.O. and Y.O.G.; investigation, O.A.O. and Y.O.G.; resources, O.A.O. and Y.O.G.; data curation, O.A.O. and Y.O.G.; writing—original draft preparation, O.A.O. and Y.O.G.; writing—review and editing, O.A.O. and Y.O.G. and M.A.O.; visualization, O.A.O. and Y.O.G.; supervision, M.A.O.; project administration, O.A.O.; funding acquisition, O.A.O. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Data availability on request.

Conflicts of Interest

There is no conflict of interest.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Omoteso, O.A.; Ghazali, Y.O.; Odeniyi, M.A. The Use of Plant-Derived Biomaterials as Drug Formulation Excipients: An Application of Biomimetics in Dosage Form Development. Proceedings 2024, 107, 42. https://doi.org/10.3390/proceedings2024107042

AMA Style

Omoteso OA, Ghazali YO, Odeniyi MA. The Use of Plant-Derived Biomaterials as Drug Formulation Excipients: An Application of Biomimetics in Dosage Form Development. Proceedings. 2024; 107(1):42. https://doi.org/10.3390/proceedings2024107042

Chicago/Turabian Style

Omoteso, Omobolanle Ayoyinka, Yusuf Oluwagbenga Ghazali, and Michael Ayodele Odeniyi. 2024. "The Use of Plant-Derived Biomaterials as Drug Formulation Excipients: An Application of Biomimetics in Dosage Form Development" Proceedings 107, no. 1: 42. https://doi.org/10.3390/proceedings2024107042

APA Style

Omoteso, O. A., Ghazali, Y. O., & Odeniyi, M. A. (2024). The Use of Plant-Derived Biomaterials as Drug Formulation Excipients: An Application of Biomimetics in Dosage Form Development. Proceedings, 107(1), 42. https://doi.org/10.3390/proceedings2024107042

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