Recent years have seen significant progress in the field of hydrogel materials, especially in terms of their modification with silver nanoparticles. A new method has been developed for producing hydrogels containing polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG), modified with silver nanoparticles, using eco-friendly components. In the synthesis process, silver azide was used as a precursor for silver nanoparticles, and an extract from Plantago lanceolata, known for its reducing and stabilizing properties, was employed. Silver nanoparticles were incorporated into the PVP and PEG hydrogel matrix, creating a unique composition with enhanced properties. The obtained hydrogels demonstrated excellent antibacterial properties due to the presence of silver nanoparticles. Tests also confirmed their biocompatibility and structural stability. Additionally, the presence of the Plantago lanceolata extract contributed to the increased bioactivity of the hydrogels. The developed hydrogels have a wide range of applications, particularly in regenerative medicine, as wound dressings; in drug delivery systems; and in cosmetology. Their antibacterial and bioactive properties make them a promising material in modern biotechnology and medicine.
This study focused mainly on investigating the physicochemical and mechanical properties of the finished systems. Methods of the physicochemical analysis included UV–Vis spectrophotometry to evaluate the absorption of silver nanoparticles, as well as a sorption capacity analysis and incubation studies in simulated body fluids. A valuable analysis of surface morphology was carried out using a high-resolution digital microscope to determine surface roughness parameters. The comprehensive studies conducted provided important information on the material characteristics of the hydrogel, which is crucial for understanding the potential applications of these materials in biomedical practice.
Author Contributions
Conceptualization, M.B. and B.T.; methodology, M.B., B.T., M.K. and K.S.; software, M.B., B.T., M.K., A.S. and C.G.; validation, M.B., B.T. and M.K.; formal analysis, M.B., K.S. and B.T.; investigation, M.B., K.S., A.S. and C.G.; resources, M.K. and B.T.; data curation, M.B. and B.T.; writing—original draft preparation, M.B., B.T. and M.K.; writing—review and editing, M.B. and B.T.; visualization, M.B., A.S., C.G. and K.S.; supervision, B.T.; project administration, B.T., M.K. and M.B.; funding acquisition, M.K. and B.T. All authors have read and agreed to the published version of the manuscript.
Funding
The research work was funded at 3rd edition of the program “Student research clubs create innovation” through the project titled, “Transdermal systems in targeted therapy of skin cancer” financed by the Ministry of Science and Higher Education (grant no: SKN 157/568410/2023).
Institutional Review Board Statement
Not applicable.
Informed Consent Statement
Not applicable.
Data Availability Statement
The data that support the findings of this study are contained within the article.
Acknowledgments
The research work was carried out within the SMART-MAT Functional Materials Science Club (section Smart-Mat) at the Faculty of Materials Engineering and Physics of the Cracow University of Technology.
Conflicts of Interest
The authors declare no conflicts of interest.
| Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
