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Open AccessProceedings

Biomolecular Detection Based on the Rotational Dynamics of Magneto-Plasmonic Nanoparticles

1
Center for Integrated Sensor Systems, Danube University Krems, 2700 Wr. Neustadt, Austria
2
PROFACTOR GmbH, 4407 Steyr-Gleink, Austria
*
Author to whom correspondence should be addressed.
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
Proceedings 2017, 1(4), 541; https://doi.org/10.3390/proceedings1040541
Published: 7 August 2017
(This article belongs to the Proceedings of Eurosensors)
We report on a nanoparticle-based biosensor that represents a label-free homogeneous bioassay suitable for in-vitro biomolecular diagnostics. The underlying detection principle is based on the optical observation of the rotational dynamics of multicomponent nanoparticles utilizing magnetic and plasmonic properties. The plasmon-optical properties of the anisotropic nanoparticles depending on their material composition and geometrical design were investigated by numerical simulations. Based on such an analysis, monodisperse magneto-plasmonic nanoparticles were fabricated using physical fabrication methods. Rotational dynamics measurements revealed the lowest detectable particle concentration in the picomolar (ng/mL) regime, which is very promising in reaching the biomolecular limit of detection which is relevant for routine clinical diagnostics.
Keywords: Magnetic-Lab-on-a-Bead; biosensor; nanoparticle; magnetic; plasmonic; point-of-care diagnostics; nanoimprint lithography; homogeneous immunoassay Magnetic-Lab-on-a-Bead; biosensor; nanoparticle; magnetic; plasmonic; point-of-care diagnostics; nanoimprint lithography; homogeneous immunoassay
MDPI and ACS Style

Shoshi, A.; Schneeweiss, P.; Haslinger, M.J.; Glatzl, T.; Kovács, G.; Schinerl, J.; Muehlberger, M.; Brueckl, H. Biomolecular Detection Based on the Rotational Dynamics of Magneto-Plasmonic Nanoparticles. Proceedings 2017, 1, 541.

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