Biomolecular Detection Based on the Rotational Dynamics of Magneto-Plasmonic Nanoparticles†
AbstractWe report on a nanoparticle-based biosensor that represents a label-free homogeneous bioassay suitable for in-vitro biomolecular diagnostics. The underlying detection principle is based on the optical observation of the rotational dynamics of multicomponent nanoparticles utilizing magnetic and plasmonic properties. The plasmon-optical properties of the anisotropic nanoparticles depending on their material composition and geometrical design were investigated by numerical simulations. Based on such an analysis, monodisperse magneto-plasmonic nanoparticles were fabricated using physical fabrication methods. Rotational dynamics measurements revealed the lowest detectable particle concentration in the picomolar (ng/mL) regime, which is very promising in reaching the biomolecular limit of detection which is relevant for routine clinical diagnostics.
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Shoshi, A.; Schneeweiss, P.; Haslinger, M.J.; Glatzl, T.; Kovács, G.; Schinerl, J.; Muehlberger, M.; Brueckl, H. Biomolecular Detection Based on the Rotational Dynamics of Magneto-Plasmonic Nanoparticles. Proceedings 2017, 1, 541.
Shoshi A, Schneeweiss P, Haslinger MJ, Glatzl T, Kovács G, Schinerl J, Muehlberger M, Brueckl H. Biomolecular Detection Based on the Rotational Dynamics of Magneto-Plasmonic Nanoparticles. Proceedings. 2017; 1(4):541.Chicago/Turabian Style
Shoshi, Astrit; Schneeweiss, Pia; Haslinger, Michael J.; Glatzl, Thomas; Kovács, Gábor; Schinerl, Judith; Muehlberger, Michael; Brueckl, Hubert. 2017. "Biomolecular Detection Based on the Rotational Dynamics of Magneto-Plasmonic Nanoparticles." Proceedings 1, no. 4: 541.
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